GO Annotations Graph

• Symbol: Sirt6
• Name: sirtuin 6
• ID: MGI:1354161

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016746	acyltransferase activity	IEA	J:60000
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:202816
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:164563
Molecular Function	GO:0003684	damaged DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0140612	DNA damage sensor activity	ISO	J:164563
Molecular Function	GO:0008047	enzyme activator activity	ISO	J:164563
Molecular Function	GO:0016757	glycosyltransferase activity	IEA	J:60000
Molecular Function	GO:0035033	histone deacetylase regulator activity	ISO	J:164563
Molecular Function	GO:0106222	lncRNA binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:278647
Molecular Function	GO:0070403	NAD+ binding	IBA	J:265628
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	IDA	J:322374
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	ISO	J:164563
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	IDA	J:322377
Molecular Function	GO:0106274	NAD+-protein-arginine ADP-ribosyltransferase activity	IDA	J:99908
Molecular Function	GO:0106274	NAD+-protein-arginine ADP-ribosyltransferase activity	IDA	J:322373
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity	ISO	J:164563
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	ISO	J:164563
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	IDA	J:322389
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	IDA	J:322389
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	IDA	J:167155
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	IDA	J:250994
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	IDA	J:322365
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	ISO	J:164563
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	IDA	J:278647
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	ISO	J:164563
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IMP	J:250994
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IMP	J:278647
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IMP	J:167155
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IMP	J:322365
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IDA	J:322389
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IMP	J:167957
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IMP	J:322375
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	TAS	Reactome:R-MMU-9604841
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IBA	J:265628
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IDA	J:278647
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	IDA	J:291806
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	ISO	J:164563
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	IDA	J:281991
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	IDA	J:288674
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	IDA	J:254113
Molecular Function	GO:0140773	NAD-dependent protein demyristoylase activity	ISO	J:164563
Molecular Function	GO:0140774	NAD-dependent protein depalmitoylase activity	ISO	J:164563
Molecular Function	GO:0031491	nucleosome binding	ISO	J:164563
Molecular Function	GO:0016779	nucleotidyltransferase activity	IEA	J:60000
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0033558	protein lysine deacetylase activity	ISO	J:155856
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:1904841	TORC2 complex binding	IDA	J:281991
Molecular Function	GO:0003714	transcription corepressor activity	IGI	J:219058
Molecular Function	GO:0003714	transcription corepressor activity	IBA	J:265628
Molecular Function	GO:0140416	transcription regulator inhibitor activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:278647
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0099115	chromosome, subtelomeric region	ISO	J:164563
Cellular Component	GO:0000781	chromosome, telomeric region	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9604828
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9604841
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:219046
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:99908
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005721	pericentric heterochromatin	ISO	J:164563
Cellular Component	GO:0090734	site of DNA damage	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Biological Process	GO:0006284	base-excision repair	IMP	J:112817
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:322375
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:214604
Biological Process	GO:0008340	determination of adult lifespan	ISO	J:164563
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:322389
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IDA	J:322373
Biological Process	GO:0006302	double-strand break repair	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	IMP	J:112817
Biological Process	GO:0016575	histone deacetylation	ISO	J:164563
Biological Process	GO:0042181	ketone biosynthetic process	IMP	J:274744
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:219058
Biological Process	GO:2000773	negative regulation of cellular senescence	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:167957
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	ISO	J:164563
Biological Process	GO:0045721	negative regulation of gluconeogenesis	ISO	J:164563
Biological Process	GO:0046325	negative regulation of glucose import	IMP	J:167957
Biological Process	GO:0045820	negative regulation of glycolytic process	IMP	J:219058
Biological Process	GO:0045820	negative regulation of glycolytic process	IMP	J:167957
Biological Process	GO:0045820	negative regulation of glycolytic process	ISO	J:164563
Biological Process	GO:0042308	negative regulation of protein import into nucleus	IMP	J:250994
Biological Process	GO:0120186	negative regulation of protein localization to chromatin	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:278647
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:250994
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	IDA	J:322377
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	IDA	J:278647
Biological Process	GO:0010529	negative regulation of transposition	IMP	J:275081
Biological Process	GO:0010529	negative regulation of transposition	IDA	J:322377
Biological Process	GO:0031508	pericentric heterochromatin formation	ISO	J:164563
Biological Process	GO:1905555	positive regulation of blood vessel branching	ISO	J:164563
Biological Process	GO:1902732	positive regulation of chondrocyte proliferation	ISO	J:164563
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:249895
Biological Process	GO:2000781	positive regulation of double-strand break repair	ISO	J:164563
Biological Process	GO:2000781	positive regulation of double-strand break repair	IDA	J:322389
Biological Process	GO:0045600	positive regulation of fat cell differentiation	IMP	J:250994
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IMP	J:112817
Biological Process	GO:1901727	positive regulation of histone deacetylase activity	ISO	J:164563
Biological Process	GO:0032024	positive regulation of insulin secretion	IDA	J:254113
Biological Process	GO:0046827	positive regulation of protein export from nucleus	ISO	J:164563
Biological Process	GO:0046827	positive regulation of protein export from nucleus	IDA	J:254113
Biological Process	GO:0120187	positive regulation of protein localization to chromatin	IMP	J:278647
Biological Process	GO:0120187	positive regulation of protein localization to chromatin	IDA	J:278647
Biological Process	GO:2000738	positive regulation of stem cell differentiation	IMP	J:322365
Biological Process	GO:2000738	positive regulation of stem cell differentiation	IMP	J:322375
Biological Process	GO:2000738	positive regulation of stem cell differentiation	ISO	J:164563
Biological Process	GO:1902459	positive regulation of stem cell population maintenance	ISO	J:164563
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:112817
Biological Process	GO:0032206	positive regulation of telomere maintenance	ISO	J:164563
Biological Process	GO:1901485	positive regulation of transcription factor catabolic process	ISO	J:164563
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0003247	post-embryonic cardiac muscle cell growth involved in heart morphogenesis	ISO	J:155856
Biological Process	GO:0006476	protein deacetylation	ISO	J:164563
Biological Process	GO:0006476	protein deacetylation	IMP	J:254113
Biological Process	GO:0051697	protein delipidation	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	IMP	J:167957
Biological Process	GO:1990166	protein localization to site of double-strand break	ISO	J:164563
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:291806
Biological Process	GO:0010569	regulation of double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:0050994	regulation of lipid catabolic process	IMP	J:281991
Biological Process	GO:0019216	regulation of lipid metabolic process	IDA	J:288674
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0050708	regulation of protein secretion	ISO	J:164563
Biological Process	GO:0009411	response to UV	ISO	J:164563
Biological Process	GO:0031509	subtelomeric heterochromatin formation	ISO	J:164563