GO Annotations Graph

• Symbol: Ttpa
• Name: tocopherol (alpha) transfer protein
• ID: MGI:1354168

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0120013	lipid transfer activity	IDA	J:197682
Molecular Function	GO:0120013	lipid transfer activity	IBA	J:265628
Molecular Function	GO:1902936	phosphatidylinositol bisphosphate binding	IBA	J:265628
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	IDA	J:197682
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IDA	J:197682
Molecular Function	GO:0019842	vitamin binding	ISO	J:155856
Molecular Function	GO:0008431	vitamin E binding	IDA	J:197682
Molecular Function	GO:0008431	vitamin E binding	ISO	J:155856
Molecular Function	GO:0008431	vitamin E binding	TAS	J:67046
Cellular Component	GO:0005737	cytoplasm	TAS	J:66419
Cellular Component	GO:0005737	cytoplasm	TAS	J:67046
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005770	late endosome	ISO	J:155856
Cellular Component	GO:0005770	late endosome	IBA	J:265628
Biological Process	GO:0001892	embryonic placenta development	IMP	J:115444
Biological Process	GO:0120009	intermembrane lipid transfer	IDA	J:197682
Biological Process	GO:0051452	intracellular pH reduction	ISO	J:155856
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0090212	negative regulation of establishment of blood-brain barrier	IMP	J:161750
Biological Process	GO:0001890	placenta development	IMP	J:67046
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	IMP	J:243822
Biological Process	GO:0009268	response to pH	ISO	J:155856
Biological Process	GO:0009636	response to toxic substance	IMP	J:161750
Biological Process	GO:0042360	vitamin E metabolic process	IMP	J:161750
Biological Process	GO:0042360	vitamin E metabolic process	ISO	J:155856
Biological Process	GO:0042360	vitamin E metabolic process	IMP	J:115444
Biological Process	GO:0042360	vitamin E metabolic process	IMP	J:67046
Biological Process	GO:0042360	vitamin E metabolic process	IMP	J:66419
Biological Process	GO:0051180	vitamin transport	IDA	J:197682
Biological Process	GO:0051180	vitamin transport	IBA	J:265628