GO Annotations Graph

• Symbol: Txnrd1
• Name: thioredoxin reductase 1
• ID: MGI:1354175

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071949	FAD binding	ISO	J:164563
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0045340	mercury ion binding	ISO	J:155856
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	ISO	J:155856
Molecular Function	GO:0050137	NADPH peroxidase activity	ISO	J:164563
Molecular Function	GO:0050137	NADPH peroxidase activity	ISO	J:155856
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	IEA	J:72247
Molecular Function	GO:0033797	selenate reductase activity	ISO	J:155856
Molecular Function	GO:0004791	thioredoxin-disulfide reductase activity	ISO	J:155856
Molecular Function	GO:0004791	thioredoxin-disulfide reductase activity	ISO	J:164563
Molecular Function	GO:0004791	thioredoxin-disulfide reductase activity	IBA	J:265628
Molecular Function	GO:0004791	thioredoxin-disulfide reductase activity	IDA	J:78793
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:60253
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:78793
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:60253
Biological Process	GO:0042537	benzene-containing compound metabolic process	ISO	J:155856
Biological Process	GO:0008283	cell population proliferation	IMP	J:96818
Biological Process	GO:0045454	cell redox homeostasis	IBA	J:265628
Biological Process	GO:0007369	gastrulation	IMP	J:124356
Biological Process	GO:0042744	hydrogen peroxide catabolic process	ISO	J:155856
Biological Process	GO:0001707	mesoderm formation	IMP	J:124356
Biological Process	GO:0070995	NADPH oxidation	ISO	J:155856
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	ISO	J:155856
Biological Process	GO:0016259	selenocysteine metabolic process	ISO	J:155856