GO Annotations Graph

• Symbol: Nox4
• Name: NADPH oxidase 4
• ID: MGI:1354184

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0072341	modified amino acid binding	ISO	J:164563
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	ISO	J:155856
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	ISO	J:155856
Molecular Function	GO:1990782	protein tyrosine kinase binding	IPI	J:237245
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	IMP	J:172977
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	IBA	J:265628
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	IMP	J:67599
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0071944	cell periphery	IDA	J:136297
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:198952
Cellular Component	GO:0043020	NADPH oxidase complex	ISO	J:155856
Cellular Component	GO:0043020	NADPH oxidase complex	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0097038	perinuclear endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:136297
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0001725	stress fiber	ISO	J:155856
Biological Process	GO:0045453	bone resorption	IMP	J:67599
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:114492
Biological Process	GO:0000902	cell morphogenesis	IMP	J:116373
Biological Process	GO:0071333	cellular response to glucose stimulus	IEP	J:136297
Biological Process	GO:0006952	defense response	IBA	J:265628
Biological Process	GO:0010467	gene expression	ISO	J:164563
Biological Process	GO:0003015	heart process	IGI	J:237245
Biological Process	GO:0003015	heart process	ISO	J:164563
Biological Process	GO:0050667	homocysteine metabolic process	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:116373
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	IMP	J:172977
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:172977
Biological Process	GO:0010729	positive regulation of hydrogen peroxide biosynthetic process	ISO	J:155856
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IMP	J:172977
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IMP	J:172977
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	IDA	J:237245
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:155856
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:155856
Biological Process	GO:0072593	reactive oxygen species metabolic process	IMP	J:172977
Biological Process	GO:0042554	superoxide anion generation	IDA	J:116373
Biological Process	GO:0042554	superoxide anion generation	IBA	J:265628
Biological Process	GO:0006801	superoxide metabolic process	ISO	J:155856
Biological Process	GO:0006801	superoxide metabolic process	ISO	J:164563