GO Annotations Graph

• Symbol: Ero1a
• Name: endoplasmic reticulum oxidoreductase 1 alpha
• ID: MGI:1354385

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071949	FAD binding	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IDA	J:95320
Molecular Function	GO:0015035	protein-disulfide reductase activity	IBA	J:265628
Molecular Function	GO:0015035	protein-disulfide reductase activity	IDA	J:158805
Molecular Function	GO:0016972	thiol oxidase activity	IEA	J:72247
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IBA	J:265628
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:60564
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0005796	Golgi lumen	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0050873	brown fat cell differentiation	IDA	J:137608
Biological Process	GO:0045454	cell redox homeostasis	ISO	J:164563
Biological Process	GO:0045454	cell redox homeostasis	IGI	J:196664
Biological Process	GO:0045454	cell redox homeostasis	IGI	J:196664
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding	ISO	J:164563
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:95320
Biological Process	GO:0030198	extracellular matrix organization	IGI	J:191281
Biological Process	GO:0030198	extracellular matrix organization	IGI	J:191281
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:153833
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IGI	J:191281
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IGI	J:191281
Biological Process	GO:0006457	protein folding	ISO	J:164563
Biological Process	GO:0006457	protein folding	IDA	J:95320
Biological Process	GO:0006457	protein folding	ISO	J:60564
Biological Process	GO:0034975	protein folding in endoplasmic reticulum	IBA	J:265628
Biological Process	GO:0022417	protein maturation by protein folding	IGI	J:191281
Biological Process	GO:0022417	protein maturation by protein folding	IGI	J:191281
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IMP	J:153833
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:153833
Biological Process	GO:0006979	response to oxidative stress	IDA	J:219362