Fbxw7 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Fbxw7
F-box and WD-40 domain protein 7
MGI:1354695

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030332	cyclin binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0050816	phosphothreonine residue binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:252001
Molecular Function	GO:0005515	protein binding	IPI	J:204747
Molecular Function	GO:0005515	protein binding	IPI	J:138546
Molecular Function	GO:0005515	protein binding	IPI	J:71503
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Molecular Function	GO:0043130	ubiquitin binding	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TAS	Reactome:R-MMU-9008715
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0097027	ubiquitin-protein transferase activator activity	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	TAS	J:71503
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9008677
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9008715
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9008717
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:73276
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:73276
Cellular Component	GO:0016020	membrane	NAS	J:204747
Cellular Component	GO:0005739	mitochondrion	IDA	J:204747
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	IDA	J:138546
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:168265
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	TAS	J:71503
Cellular Component	GO:0005634	nucleus	IDA	J:138546
Cellular Component	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:168265
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	ISO	J:164563
Biological Process	GO:0034644	cellular response to UV	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0030324	lung development	IMP	J:172214
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:2001205	negative regulation of osteoclast development	IMP	J:251942
Biological Process	GO:2001205	negative regulation of osteoclast development	ISO	J:164563
Biological Process	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	IDA	J:138546
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:71503
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP	J:204747
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	ISO	J:164563
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	IMP	J:204747
Biological Process	GO:1903955	positive regulation of protein targeting to mitochondrion	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	IMP	J:271692
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0031648	protein destabilization	IDA	J:138546
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	ISO	J:79007
Biological Process	GO:1903146	regulation of autophagy of mitochondrion	ISO	J:164563
Biological Process	GO:0090049	regulation of cell migration involved in sprouting angiogenesis	IMP	J:219052
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:271692
Biological Process	GO:0042752	regulation of circadian rhythm	ISO	J:164563
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA	J:252001
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0007062	sister chromatid cohesion	ISO	J:164563
Biological Process	GO:0010992	ubiquitin recycling	IBA	J:265628
Biological Process	GO:0001570	vasculogenesis	IMP	J:172214

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/02/2024 MGI 6.24