Fbxw7 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Fbxw7
F-box and WD-40 domain protein 7
MGI:1354695

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030332	cyclin binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0050816	phosphothreonine residue binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:252001
Molecular Function	GO:0005515	protein binding	IPI	J:204747
Molecular Function	GO:0005515	protein binding	IPI	J:138546
Molecular Function	GO:0005515	protein binding	IPI	J:71503
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Molecular Function	GO:0043130	ubiquitin binding	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TAS	Reactome:R-MMU-9008715
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0097027	ubiquitin-protein transferase activator activity	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	TAS	J:71503
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9008677
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9008715
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9008717
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:73276
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:73276
Cellular Component	GO:0016020	membrane	NAS	J:204747
Cellular Component	GO:0005739	mitochondrion	IDA	J:204747
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	IDA	J:138546
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:168265
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	TAS	J:71503
Cellular Component	GO:0005634	nucleus	IDA	J:138546
Cellular Component	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:168265
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	ISO	J:164563
Biological Process	GO:0034644	cellular response to UV	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0030324	lung development	IMP	J:172214
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:2001205	negative regulation of osteoclast development	IMP	J:251942
Biological Process	GO:2001205	negative regulation of osteoclast development	ISO	J:164563
Biological Process	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	IDA	J:138546
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:71503
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP	J:204747
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	ISO	J:164563
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	IMP	J:204747
Biological Process	GO:1903955	positive regulation of protein targeting to mitochondrion	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	IMP	J:271692
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0031648	protein destabilization	IDA	J:138546
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	ISO	J:79007
Biological Process	GO:1903146	regulation of autophagy of mitochondrion	ISO	J:164563
Biological Process	GO:0090049	regulation of cell migration involved in sprouting angiogenesis	IMP	J:219052
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:271692
Biological Process	GO:0042752	regulation of circadian rhythm	ISO	J:164563
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA	J:252001
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0007062	sister chromatid cohesion	ISO	J:164563
Biological Process	GO:0010992	ubiquitin recycling	IBA	J:265628
Biological Process	GO:0001570	vasculogenesis	IMP	J:172214

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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