GO Annotations Graph

• Symbol: Kdm2b
• Name: lysine (K)-specific demethylase 2B
• ID: MGI:1354737

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0032452	histone demethylase activity	TAS	J:171291
Molecular Function	GO:0032452	histone demethylase activity	IBA	J:265628
Molecular Function	GO:0051864	histone H3K36 demethylase activity	ISO	J:164563
Molecular Function	GO:0051864	histone H3K36 demethylase activity	IDA	J:186946
Molecular Function	GO:0140680	histone H3K36me/H3K36me2 demethylase activity	IEA	J:72245
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:122905
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:182882
Molecular Function	GO:0019843	rRNA binding	IEA	J:60000
Molecular Function	GO:0003712	transcription coregulator activity	IBA	J:265628
Molecular Function	GO:0045322	unmethylated CpG binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0031519	PcG protein complex	ISO	J:164563
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006338	chromatin remodeling	ISO	J:164563
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	IMP	J:171291
Biological Process	GO:0030900	forebrain development	IMP	J:171291
Biological Process	GO:0021592	fourth ventricle development	IMP	J:171291
Biological Process	GO:0030902	hindbrain development	IMP	J:171291
Biological Process	GO:0021993	initiation of neural tube closure	IMP	J:171291
Biological Process	GO:0021670	lateral ventricle development	IMP	J:171291
Biological Process	GO:0030901	midbrain development	IMP	J:171291
Biological Process	GO:0021555	midbrain-hindbrain boundary morphogenesis	IMP	J:171291
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	IMP	J:171291
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:171291
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:171291
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:186946
Biological Process	GO:0030307	positive regulation of cell growth	IDA	J:186946
Biological Process	GO:1902459	positive regulation of stem cell population maintenance	IDA	J:186946
Biological Process	GO:0006482	protein demethylation	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0007283	spermatogenesis	IMP	J:171291
Biological Process	GO:0021678	third ventricle development	IMP	J:171291