GO Annotations Graph

• Symbol: Socs1
• Name: suppressor of cytokine signaling 1
• ID: MGI:1354910

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	IBA	J:265628
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0019210	kinase inhibitor activity	IDA	J:43733
Molecular Function	GO:0019210	kinase inhibitor activity	IDA	J:52380
Molecular Function	GO:0005515	protein binding	IPI	J:79351
Molecular Function	GO:0005515	protein binding	IPI	J:43733
Molecular Function	GO:0005515	protein binding	IPI	J:74765
Molecular Function	GO:0005515	protein binding	IPI	J:91027
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1169194
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1524177
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-912695
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9705455
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9705471
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9707972
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9707979
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	IBA	J:265628
Biological Process	GO:0071230	cellular response to amino acid stimulus	IDA	J:164409
Biological Process	GO:0071345	cellular response to cytokine stimulus	ISO	J:150450
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:150450
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:43734
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:43733
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IMP	J:72528
Biological Process	GO:0045444	fat cell differentiation	IMP	J:100915
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0030225	macrophage differentiation	ISO	J:164563
Biological Process	GO:0043377	negative regulation of CD8-positive, alpha-beta T cell differentiation	IMP	J:258710
Biological Process	GO:1904898	negative regulation of hepatic stellate cell proliferation	ISO	J:155856
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	IDA	J:91027
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	IMP	J:69472
Biological Process	GO:0009968	negative regulation of signal transduction	IEA	J:60000
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	IDA	J:43734
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	IBA	J:265628
Biological Process	GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation	IMP	J:258710
Biological Process	GO:2000271	positive regulation of fibroblast apoptotic process	ISO	J:155856
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	ISO	J:164563
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IDA	J:74765
Biological Process	GO:0010533	regulation of activation of Janus kinase activity	IMP	J:173334
Biological Process	GO:0001817	regulation of cytokine production	IMP	J:173334
Biological Process	GO:0040008	regulation of growth	IEA	J:60000
Biological Process	GO:0001932	regulation of protein phosphorylation	IDA	J:91027
Biological Process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	IMP	J:173334
Biological Process	GO:0060334	regulation of type II interferon-mediated signaling pathway	IEA	J:72247
Biological Process	GO:0042509	regulation of tyrosine phosphorylation of STAT protein	IMP	J:173334