GO Annotations Graph

• Symbol: Dlc1
• Name: deleted in liver cancer 1
• ID: MGI:1354949

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:155856
Molecular Function	GO:0005096	GTPase activator activity	IBA	J:265628
Molecular Function	GO:0008289	lipid binding	IEA	J:72247
Molecular Function	GO:0043274	phospholipase binding	ISO	J:155856
Molecular Function	GO:0042169	SH2 domain binding	ISO	J:164563
Molecular Function	GO:0017166	vinculin binding	ISO	J:155856
Cellular Component	GO:0005884	actin filament	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0030864	cortical actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	IBA	J:265628
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Cellular Component	GO:0001725	stress fiber	ISO	J:155856
Biological Process	GO:0030036	actin cytoskeleton organization	IBA	J:265628
Biological Process	GO:0030036	actin cytoskeleton organization	IMP	J:96194
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0007202	activation of phospholipase C activity	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0007010	cytoskeleton organization	ISO	J:155856
Biological Process	GO:0048041	focal adhesion assembly	IMP	J:96194
Biological Process	GO:0030900	forebrain development	IMP	J:96194
Biological Process	GO:0003007	heart morphogenesis	IMP	J:96194
Biological Process	GO:0021575	hindbrain morphogenesis	IMP	J:96194
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0051497	negative regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0001843	neural tube closure	IMP	J:96194
Biological Process	GO:1900119	positive regulation of execution phase of apoptosis	ISO	J:164563
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	ISO	J:164563
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563
Biological Process	GO:0035023	regulation of Rho protein signal transduction	IBA	J:265628
Biological Process	GO:0007165	signal transduction	IEA	J:72247