GO Annotations Graph

• Symbol: Tlr5
• Name: toll-like receptor 5
• ID: MGI:1858171

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005149	interleukin-1 receptor binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:189211
Molecular Function	GO:0038023	signaling receptor activity	IBA	J:265628
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Cellular Component	GO:0016020	membrane	ISO	J:155856
Biological Process	GO:0042742	defense response to bacterium	IEA	J:72247
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:72247
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IEA	J:72247
Biological Process	GO:0001819	positive regulation of cytokine production	IEA	J:72247
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0034123	positive regulation of toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0001817	regulation of cytokine production	IEA	J:72247
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0034146	toll-like receptor 5 signaling pathway	IEA	J:72247
Biological Process	GO:0002224	toll-like receptor signaling pathway	IBA	J:265628