GO Annotations Graph

• Symbol: Nucb2
• Name: nucleobindin 2
• ID: MGI:1858179

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0005509	calcium ion binding	IDA	J:63800
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001965	G-protein alpha-subunit binding	ISO	J:155856
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:63800
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:63800
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	ISO	J:164563
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005797	Golgi medial cisterna	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005640	nuclear outer membrane	IDA	J:63800
Cellular Component	GO:0005634	nucleus	IDA	J:63800
Biological Process	GO:1901142	insulin metabolic process	ISO	J:155856
Biological Process	GO:0006874	intracellular calcium ion homeostasis	TAS	J:63800
Biological Process	GO:0032099	negative regulation of appetite	ISO	J:155856
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:0045599	negative regulation of fat cell differentiation	ISO	J:155856
Biological Process	GO:0070093	negative regulation of glucagon secretion	ISO	J:155856
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0046321	positive regulation of fatty acid oxidation	ISO	J:155856
Biological Process	GO:2000845	positive regulation of testosterone secretion	ISO	J:155856
Biological Process	GO:0007264	small GTPase mediated signal transduction	ISO	J:155856