GO Annotations Graph

• Symbol: Tnk2
• Name: tyrosine kinase, non-receptor, 2
• ID: MGI:1858308

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA	J:72245
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:158889
Molecular Function	GO:0005515	protein binding	IPI	J:170793
Molecular Function	GO:0005515	protein binding	IPI	J:170793
Molecular Function	GO:0005515	protein binding	IPI	J:123889
Molecular Function	GO:0005515	protein binding	IPI	J:111029
Molecular Function	GO:0005515	protein binding	IPI	J:100995
Molecular Function	GO:0005515	protein binding	IPI	J:143609
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:73065
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0050699	WW domain binding	IPI	J:170793
Cellular Component	GO:0030424	axon	IDA	J:100995
Cellular Component	GO:0030424	axon	IDA	J:100995
Cellular Component	GO:0030424	axon	IDA	J:100995
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:164563
Cellular Component	GO:0030136	clathrin-coated vesicle	ISO	J:164563
Cellular Component	GO:0097268	cytoophidium	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0030425	dendrite	IDA	J:100995
Cellular Component	GO:0030425	dendrite	IDA	J:100995
Cellular Component	GO:0030425	dendrite	IDA	J:100995
Cellular Component	GO:0005768	endosome	IDA	J:123889
Cellular Component	GO:0070436	Grb2-EGFR complex	ISO	J:164563
Cellular Component	GO:0030426	growth cone	IDA	J:100995
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	IDA	J:100995
Cellular Component	GO:0043025	neuronal cell body	IDA	J:100995
Cellular Component	GO:0043025	neuronal cell body	IDA	J:100995
Cellular Component	GO:0005634	nucleus	IDA	J:158889
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:158889
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0016310	phosphorylation	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:2000369	regulation of clathrin-dependent endocytosis	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0007286	spermatid development	IGI	J:266475