GO Annotations Graph

• Symbol: Ngef
• Name: neuronal guanine nucleotide exchange factor
• ID: MGI:1858414

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046875	ephrin receptor binding	IPI	J:117343
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:117343
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-3928621
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:117343
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:117343
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:117343
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:117343
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:117343
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:117343
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Biological Process	GO:0090630	activation of GTPase activity	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0048013	ephrin receptor signaling pathway	IDA	J:117343
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0061002	negative regulation of dendritic spine morphogenesis	IDA	J:117343
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0043087	regulation of GTPase activity	IDA	J:117343
Biological Process	GO:1905806	regulation of synapse pruning	IDA	J:117343
Biological Process	GO:1905806	regulation of synapse pruning	IMP	J:117343
Biological Process	GO:1905806	regulation of synapse pruning	IEP	J:117343
Biological Process	GO:1905806	regulation of synapse pruning	IDA	J:117343
Biological Process	GO:1905806	regulation of synapse pruning	IMP	J:117343
Biological Process	GO:1905806	regulation of synapse pruning	IDA	J:117343