GO Annotations Graph

• Symbol: Sec61a1
• Name: SEC61 translocon subunit alpha 1
• ID: MGI:1858417

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005262	calcium channel activity	ISO	J:164563
Molecular Function	GO:0008320	protein transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0043022	ribosome binding	ISO	J:164563
Molecular Function	GO:0043022	ribosome binding	IBA	J:265628
Molecular Function	GO:0043022	ribosome binding	IDA	J:109619
Molecular Function	GO:0005048	signal sequence binding	IBA	J:265628
Molecular Function	GO:0022857	transmembrane transporter activity	EXP	J:231205
Molecular Function	GO:0022857	transmembrane transporter activity	EXP	J:231204
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:197701
Cellular Component	GO:0030670	phagocytic vesicle membrane	TAS	Reactome:R-NUL-1236959
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005784	Sec61 translocon complex	IBA	J:265628
Biological Process	GO:0016049	cell growth	ISO	J:197701
Biological Process	GO:0006613	cotranslational protein targeting to membrane	ISO	J:164563
Biological Process	GO:0007029	endoplasmic reticulum organization	ISO	J:197701
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	ISO	J:197701
Biological Process	GO:0031204	post-translational protein targeting to membrane, translocation	ISO	J:164563
Biological Process	GO:0031204	post-translational protein targeting to membrane, translocation	IBA	J:265628
Biological Process	GO:0039019	pronephric nephron development	IMP	J:237692
Biological Process	GO:0045048	protein insertion into ER membrane	ISO	J:164563
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0015031	protein transport	IEA	J:72247
Biological Process	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	ISO	J:197701
Biological Process	GO:0006616	SRP-dependent cotranslational protein targeting to membrane, translocation	IBA	J:265628