GO Annotations Graph

• Symbol: Bok
• Name: BCL2-related ovarian killer
• ID: MGI:1858494

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051400	BH domain binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:234802
Molecular Function	GO:0005515	protein binding	IPI	J:203544
Molecular Function	GO:0005515	protein binding	IPI	J:203544
Molecular Function	GO:0046983	protein dimerization activity	ISO	J:155856
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:155856
Molecular Function	GO:0046982	protein heterodimerization activity	IBA	J:265628
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:228257
Molecular Function	GO:0042803	protein homodimerization activity	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:203544
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IPI	J:235310
Cellular Component	GO:0033106	cis-Golgi network membrane	IDA	J:228257
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031901	early endosome membrane	IDA	J:228257
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:235310
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:228257
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:164563
Cellular Component	GO:0031966	mitochondrial membrane	IDA	J:235310
Cellular Component	GO:0031966	mitochondrial membrane	IDA	J:228257
Cellular Component	GO:0005741	mitochondrial outer membrane	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0055038	recycling endosome membrane	IDA	J:228257
Cellular Component	GO:0032588	trans-Golgi network membrane	IDA	J:228257
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	IMP	J:223399
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0006921	cellular component disassembly involved in execution phase of apoptosis	IDA	J:228257
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IBA	J:265628
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	ISO	J:164563
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IBA	J:265628
Biological Process	GO:0051902	negative regulation of mitochondrial depolarization	IMP	J:235305
Biological Process	GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IMP	J:235305
Biological Process	GO:0060546	negative regulation of necroptotic process	IMP	J:235305
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:235305
Biological Process	GO:0051402	neuron apoptotic process	IDA	J:61844
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP	J:223399
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IDA	J:235310
Biological Process	GO:1900119	positive regulation of execution phase of apoptosis	ISO	J:164563
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	IDA	J:228257
Biological Process	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA	J:235310
Biological Process	GO:1903899	positive regulation of PERK-mediated unfolded protein response	IMP	J:223399
Biological Process	GO:0051259	protein complex oligomerization	IDA	J:235310
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0010506	regulation of autophagy	ISO	J:164563
Biological Process	GO:1901382	regulation of chorionic trophoblast cell proliferation	ISO	J:164563
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	IMP	J:235305
Biological Process	GO:1904708	regulation of granulosa cell apoptotic process	ISO	J:164563
Biological Process	GO:0001836	release of cytochrome c from mitochondria	ISO	J:164563