GO Annotations Graph

• Symbol: Keap1
• Name: kelch-like ECH-associated protein 1
• ID: MGI:1858732

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0097718	disordered domain specific binding	IPI	J:240280
Molecular Function	GO:0042802	identical protein binding	IPI	J:157548
Molecular Function	GO:0042802	identical protein binding	IMP	J:240280
Molecular Function	GO:0005515	protein binding	IPI	J:292826
Molecular Function	GO:0005515	protein binding	IPI	J:135362
Molecular Function	GO:0005515	protein binding	IPI	J:162670
Molecular Function	GO:0005515	protein binding	IPI	J:222136
Molecular Function	GO:0005515	protein binding	IPI	J:279942
Molecular Function	GO:0005515	protein binding	IPI	J:172945
Molecular Function	GO:0005515	protein binding	IPI	J:203811
Molecular Function	GO:0005515	protein binding	IPI	J:78097
Molecular Function	GO:0005515	protein binding	IPI	J:219149
Molecular Function	GO:0005515	protein binding	IPI	J:85958
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IBA	J:265628
Cellular Component	GO:0005884	actin filament	IDA	J:219105
Cellular Component	GO:0005912	adherens junction	ISO	J:155856
Cellular Component	GO:0034451	centriolar satellite	ISO	J:164563
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	IDA	J:279946
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	IDA	J:279942
Cellular Component	GO:0005737	cytoplasm	IDA	J:279946
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IPI	J:85958
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:85958
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0016234	inclusion body	IDA	J:162670
Cellular Component	GO:0016234	inclusion body	IDA	J:172945
Cellular Component	GO:0016234	inclusion body	ISO	J:164563
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IMP	J:240280
Biological Process	GO:0071322	cellular response to carbohydrate stimulus	ISO	J:155856
Biological Process	GO:0071353	cellular response to interleukin-4	IDA	J:62630
Biological Process	GO:0034599	cellular response to oxidative stress	IDA	J:279946
Biological Process	GO:0034599	cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:0034599	cellular response to oxidative stress	IDA	J:279942
Biological Process	GO:0042994	cytoplasmic sequestering of transcription factor	ISO	J:155856
Biological Process	GO:0042994	cytoplasmic sequestering of transcription factor	IBA	J:265628
Biological Process	GO:0001701	in utero embryonic development	IMP	J:89567
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	IDA	J:279942
Biological Process	GO:0016567	protein ubiquitination	IDA	J:279946
Biological Process	GO:0010506	regulation of autophagy	ISO	J:164563
Biological Process	GO:0010506	regulation of autophagy	IDA	J:172945
Biological Process	GO:0010506	regulation of autophagy	IDA	J:162670
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:89567
Biological Process	GO:0045604	regulation of epidermal cell differentiation	IMP	J:89567
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IDA	J:279942
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IDA	J:279946
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563