Irf3 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Irf3
interferon regulatory factor 3
MGI:1859179

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001216	DNA-binding transcription activator activity	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IMP	J:235021
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	IPI	J:236952
Molecular Function	GO:0042802	identical protein binding	IPI	J:154027
Molecular Function	GO:0042802	identical protein binding	IPI	J:153697
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:86256
Molecular Function	GO:0042802	identical protein binding	ISO	J:280922
Molecular Function	GO:0042802	identical protein binding	IPI	J:84679
Molecular Function	GO:0042802	identical protein binding	IPI	J:84679
Molecular Function	GO:0042802	identical protein binding	IPI	J:84896
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:141299
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0140537	transcription regulator activator activity	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1810458
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:173334
Cellular Component	GO:0005634	nucleus	IDA	J:96405
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:173334
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0098586	cellular response to virus	IDA	J:141299
Biological Process	GO:0002753	cytosolic pattern recognition receptor signaling pathway	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	IMP	J:235021
Biological Process	GO:0051607	defense response to virus	IMP	J:153410
Biological Process	GO:0051607	defense response to virus	IMP	J:167950
Biological Process	GO:0051607	defense response to virus	IMP	J:199310
Biological Process	GO:0002376	immune system process	IBA	J:265628
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	J:84679
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	J:84896
Biological Process	GO:0009299	mRNA transcription	ISO	J:164563
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:235021
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:155856
Biological Process	GO:0032727	positive regulation of interferon-alpha production	IMP	J:153410
Biological Process	GO:0032728	positive regulation of interferon-beta production	IMP	J:153410
Biological Process	GO:0032728	positive regulation of interferon-beta production	TAS	J:184127
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISO	J:280922
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032481	positive regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	IMP	J:123411
Biological Process	GO:0097300	programmed necrotic cell death	IMP	J:199310
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0010468	regulation of gene expression	IGI	J:191073
Biological Process	GO:0050727	regulation of inflammatory response	IGI	J:239522
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0009617	response to bacterium	IDA	J:96405
Biological Process	GO:0043330	response to exogenous dsRNA	IDA	J:84896
Biological Process	GO:0043330	response to exogenous dsRNA	IDA	J:84679
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:84679
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:84896
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032606	type I interferon production	IGI	J:97662
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	IMP	J:235021

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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