GO Annotations Graph

• Symbol: Irf6
• Name: interferon regulatory factor 6
• ID: MGI:1859211

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:153386
Molecular Function	GO:0003677	DNA binding	IMP	J:153386
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:153386
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:153386
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:273515
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IEA	J:72247
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0048468	cell development	IMP	J:116077
Biological Process	GO:0048468	cell development	IMP	J:116077
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0008283	cell population proliferation	IGI	J:116077
Biological Process	GO:1904888	cranial skeletal system development	IMP	J:115343
Biological Process	GO:0002376	immune system process	IBA	J:265628
Biological Process	GO:0030216	keratinocyte differentiation	IMP	J:115343
Biological Process	GO:0030216	keratinocyte differentiation	IMP	J:116077
Biological Process	GO:0030216	keratinocyte differentiation	IMP	J:115343
Biological Process	GO:0043616	keratinocyte proliferation	IMP	J:115343
Biological Process	GO:0043616	keratinocyte proliferation	IMP	J:116077
Biological Process	GO:0043616	keratinocyte proliferation	IGI	J:116077
Biological Process	GO:0043616	keratinocyte proliferation	IMP	J:115343
Biological Process	GO:0043616	keratinocyte proliferation	IGI	J:116077
Biological Process	GO:0060173	limb development	IMP	J:115343
Biological Process	GO:0060644	mammary gland epithelial cell differentiation	IEP	J:153307
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	IGI	J:116077
Biological Process	GO:2000647	negative regulation of stem cell proliferation	IGI	J:116077
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:153386
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0060021	roof of mouth development	IMP	J:174027
Biological Process	GO:0043588	skin development	IMP	J:115343
Biological Process	GO:0043588	skin development	IGI	J:116077
Biological Process	GO:0043588	skin development	IMP	J:115343
Biological Process	GO:0043588	skin development	IMP	J:116077
Biological Process	GO:0072089	stem cell proliferation	IGI	J:116077
Biological Process	GO:0072089	stem cell proliferation	IGI	J:116077