GO Annotations Graph

• Symbol: Il36a
• Name: interleukin 36A
• ID: MGI:1859324

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IGI	J:178804
Molecular Function	GO:0005149	interleukin-1 receptor binding	ISS	J:61590
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:152397
Cellular Component	GO:0005615	extracellular space	IDA	J:178804
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IBA	J:265628
Biological Process	GO:0001816	cytokine production	IDA	J:178804
Biological Process	GO:0001816	cytokine production	IDA	J:178804
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	TAS	J:61590
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	IBA	J:265628
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0032635	interleukin-6 production	IGI	J:178804
Biological Process	GO:0032635	interleukin-6 production	IGI	J:178804
Biological Process	GO:0001819	positive regulation of cytokine production	IDA	J:178804
Biological Process	GO:0010628	positive regulation of gene expression	IBA	J:265628
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IGI	J:178804
Biological Process	GO:0007165	signal transduction	IGI	J:178804