GO Annotations Graph

• Symbol: Mefv
• Name: Mediterranean fever
• ID: MGI:1859396

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0008270	zinc ion binding	NAS	J:62515
Cellular Component	GO:0061702	canonical inflammasome complex	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005874	microtubule	NAS	J:263129
Cellular Component	GO:0005875	microtubule associated complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032695	negative regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0071641	negative regulation of macrophage inflammatory protein 1 alpha production	ISO	J:164563
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	NAS	J:319676
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:2001056	positive regulation of cysteine-type endopeptidase activity	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:259950
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:259950
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	IBA	J:265628
Biological Process	GO:0070269	pyroptosis	NAS	J:319676
Biological Process	GO:1904270	pyroptosome complex assembly	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IBA	J:265628
Biological Process	GO:0032651	regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0034341	response to type II interferon	ISO	J:164563