GO Annotations Graph

• Symbol: Pdgfc
• Name: platelet-derived growth factor, C polypeptide
• ID: MGI:1859631

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008083	growth factor activity	IEA	J:72247
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	IDA	J:93392
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	IDA	J:62052
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IDA	J:62052
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	IDA	J:62052
Biological Process	GO:0009887	animal organ morphogenesis	IGI	J:93954
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:93954
Biological Process	GO:0060348	bone development	IGI	J:205009
Biological Process	GO:0071230	cellular response to amino acid stimulus	IDA	J:164409
Biological Process	GO:0048565	digestive tract development	IGI	J:205009
Biological Process	GO:0048568	embryonic organ development	IEA	J:72247
Biological Process	GO:0048144	fibroblast proliferation	IDA	J:93354
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IDA	J:93392
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0030335	positive regulation of cell migration	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:62052
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:240338
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IDA	J:93354
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IBA	J:265628
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	IBA	J:265628
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IDA	J:77668