GO Annotations Graph

• Symbol: Prdx4
• Name: peroxiredoxin 4
• ID: MGI:1859815

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016209	antioxidant activity	IEA	J:72247
Molecular Function	GO:0016209	antioxidant activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	IPI	J:178177
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0140313	molecular sequestering activity	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0004601	peroxidase activity	IEA	J:60000
Molecular Function	GO:0051920	peroxiredoxin activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:247415
Molecular Function	GO:0008379	thioredoxin peroxidase activity	IBA	J:265628
Molecular Function	GO:0140824	thioredoxin-dependent peroxiredoxin activity	IEA	J:72245
Cellular Component	GO:0005737	cytoplasm	IDA	J:62333
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:178177
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:178177
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005790	smooth endoplasmic reticulum	ISO	J:155856
Biological Process	GO:0045454	cell redox homeostasis	IBA	J:265628
Biological Process	GO:0045454	cell redox homeostasis	IGI	J:196664
Biological Process	GO:0045454	cell redox homeostasis	IGI	J:196664
Biological Process	GO:0033554	cellular response to stress	IBA	J:265628
Biological Process	GO:0030198	extracellular matrix organization	IGI	J:191281
Biological Process	GO:0030198	extracellular matrix organization	IGI	J:191281
Biological Process	GO:0042744	hydrogen peroxide catabolic process	IBA	J:265628
Biological Process	GO:0008584	male gonad development	IMP	J:149074
Biological Process	GO:2000255	negative regulation of male germ cell proliferation	IMP	J:149074
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IGI	J:191281
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IGI	J:191281
Biological Process	GO:0022417	protein maturation by protein folding	IGI	J:191281
Biological Process	GO:0022417	protein maturation by protein folding	IGI	J:191281
Biological Process	GO:0072593	reactive oxygen species metabolic process	IDA	J:62333
Biological Process	GO:0006979	response to oxidative stress	IBA	J:265628
Biological Process	GO:0006979	response to oxidative stress	IMP	J:149074
Biological Process	GO:0007283	spermatogenesis	IMP	J:149074