GO Annotations Graph

• Symbol: Prdx5
• Name: peroxiredoxin 5
• ID: MGI:1859821

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016209	antioxidant activity	ISO	J:164563
Molecular Function	GO:0016209	antioxidant activity	ISS	J:58008
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0004601	peroxidase activity	ISO	J:164563
Molecular Function	GO:0072541	peroxynitrite reductase activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:263469
Molecular Function	GO:0001016	RNA polymerase III transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISS	J:58008
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0008379	thioredoxin peroxidase activity	ISO	J:164563
Molecular Function	GO:0008379	thioredoxin peroxidase activity	ISO	J:164563
Molecular Function	GO:0008379	thioredoxin peroxidase activity	IBA	J:265628
Molecular Function	GO:0140824	thioredoxin-dependent peroxiredoxin activity	IDA	J:333123
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISS	J:58008
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005782	peroxisomal matrix	ISS	J:58008
Cellular Component	GO:0005782	peroxisomal matrix	ISO	J:164563
Cellular Component	GO:0005777	peroxisome	ISO	J:164563
Cellular Component	GO:0005777	peroxisome	ISO	J:155856
Cellular Component	GO:0005777	peroxisome	ISO	J:164563
Cellular Component	GO:0005777	peroxisome	IBA	J:265628
Biological Process	GO:0045454	cell redox homeostasis	IBA	J:265628
Biological Process	GO:0034599	cellular response to oxidative stress	IBA	J:265628
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:164563
Biological Process	GO:0042744	hydrogen peroxide catabolic process	ISS	J:58008
Biological Process	GO:0042744	hydrogen peroxide catabolic process	ISO	J:164563
Biological Process	GO:0042744	hydrogen peroxide catabolic process	IBA	J:265628
Biological Process	GO:0070995	NADPH oxidation	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0051354	negative regulation of oxidoreductase activity	ISO	J:164563
Biological Process	GO:0016480	negative regulation of transcription by RNA polymerase III	ISO	J:164563
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:164563
Biological Process	GO:2001057	reactive nitrogen species metabolic process	ISO	J:164563
Biological Process	GO:0060785	regulation of apoptosis involved in tissue homeostasis	ISO	J:164563
Biological Process	GO:0006979	response to oxidative stress	ISO	J:164563
Biological Process	GO:0006979	response to oxidative stress	ISO	J:164563
Biological Process	GO:0006979	response to oxidative stress	ISS	J:58008