GO Annotations Graph

• Symbol: Syt8
• Name: synaptotagmin VIII
• ID: MGI:1859867

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	IBA	J:265628
Molecular Function	GO:0048306	calcium-dependent protein binding	IPI	J:99919
Molecular Function	GO:0048306	calcium-dependent protein binding	IPI	J:99919
Molecular Function	GO:0030276	clathrin binding	ISO	J:155856
Molecular Function	GO:0030276	clathrin binding	IBA	J:265628
Molecular Function	GO:0001786	phosphatidylserine binding	IBA	J:265628
Molecular Function	GO:0019905	syntaxin binding	IBA	J:265628
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0031045	dense core granule	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0030672	synaptic vesicle membrane	IBA	J:265628
Biological Process	GO:0007340	acrosome reaction	IDA	J:99919
Biological Process	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	IBA	J:265628
Biological Process	GO:0071277	cellular response to calcium ion	IBA	J:265628
Biological Process	GO:0006887	exocytosis	IEA	J:72247
Biological Process	GO:0017158	regulation of calcium ion-dependent exocytosis	IBA	J:265628
Biological Process	GO:0014059	regulation of dopamine secretion	IBA	J:265628
Biological Process	GO:0048488	synaptic vesicle endocytosis	IBA	J:265628