GO Annotations Graph

• Symbol: Insm1
• Name: insulinoma-associated 1
• ID: MGI:1859980

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:164563
Molecular Function	GO:0030332	cyclin binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:77887
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:77887
Cellular Component	GO:0017053	transcription repressor complex	ISO	J:164563
Cellular Component	GO:0017053	transcription repressor complex	IBA	J:265628
Biological Process	GO:0061104	adrenal chromaffin cell differentiation	IMP	J:130853
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0016477	cell migration	IMP	J:214095
Biological Process	GO:0008283	cell population proliferation	IMP	J:214095
Biological Process	GO:0031018	endocrine pancreas development	IMP	J:106988
Biological Process	GO:0035270	endocrine system development	IMP	J:112173
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0030182	neuron differentiation	IBA	J:265628
Biological Process	GO:0003358	noradrenergic neuron development	IMP	J:130853
Biological Process	GO:0042421	norepinephrine biosynthetic process	IMP	J:130853
Biological Process	GO:0003310	pancreatic A cell differentiation	IDA	J:106988
Biological Process	GO:0003310	pancreatic A cell differentiation	IMP	J:106988
Biological Process	GO:0045597	positive regulation of cell differentiation	IMP	J:130853
Biological Process	GO:0030335	positive regulation of cell migration	IMP	J:214095
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:214095
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	IMP	J:130853
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0010564	regulation of cell cycle process	IBA	J:265628
Biological Process	GO:0010468	regulation of gene expression	IMP	J:130853
Biological Process	GO:0043254	regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0061549	sympathetic ganglion development	IMP	J:130853
Biological Process	GO:0060290	transdifferentiation	ISO	J:164563
Biological Process	GO:0003323	type B pancreatic cell development	IMP	J:112173
Biological Process	GO:0003309	type B pancreatic cell differentiation	IDA	J:106988
Biological Process	GO:0003309	type B pancreatic cell differentiation	IMP	J:106988