GO Annotations Graph

• Symbol: Pck2
• Name: phosphoenolpyruvate carboxykinase 2 (mitochondrial)
• ID: MGI:1860456

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016831	carboxy-lyase activity	IEA	J:60000
Molecular Function	GO:0005525	GTP binding	IEA	J:60000
Molecular Function	GO:0005525	GTP binding	IEA	J:72247
Molecular Function	GO:0016829	lyase activity	IEA	J:60000
Molecular Function	GO:0030145	manganese ion binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	ISO	J:164563
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	ISO	J:155856
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	IBA	J:265628
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	IDA	J:326573
Molecular Function	GO:0004611	phosphoenolpyruvate carboxykinase activity	ISO	J:155856
Molecular Function	GO:0017076	purine nucleotide binding	IEA	J:72247
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005759	mitochondrial matrix	IDA	J:326573
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	IBA	J:265628
Biological Process	GO:0071333	cellular response to glucose stimulus	IBA	J:265628
Biological Process	GO:0032869	cellular response to insulin stimulus	IBA	J:265628
Biological Process	GO:0006094	gluconeogenesis	ISO	J:155856
Biological Process	GO:0006094	gluconeogenesis	IBA	J:265628
Biological Process	GO:0006094	gluconeogenesis	ISO	J:326646
Biological Process	GO:0006094	gluconeogenesis	IGI	J:326573
Biological Process	GO:0046327	glycerol biosynthetic process from pyruvate	IBA	J:265628
Biological Process	GO:0070365	hepatocyte differentiation	IBA	J:265628
Biological Process	GO:0006116	NADH oxidation	ISO	J:155856
Biological Process	GO:0006107	oxaloacetate metabolic process	ISO	J:155856
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0019543	propionate catabolic process	IBA	J:265628
Biological Process	GO:0006090	pyruvate metabolic process	ISO	J:155856
Biological Process	GO:0042594	response to starvation	IBA	J:265628