GO Annotations Graph

• Symbol: Plek
• Name: pleckstrin
• ID: MGI:1860485

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0031532	actin cytoskeleton reorganization	IBA	J:265628
Biological Process	GO:0030030	cell projection organization	ISO	J:164563
Biological Process	GO:0030866	cortical actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010920	negative regulation of inositol phosphate biosynthetic process	ISO	J:164563
Biological Process	GO:0046488	phosphatidylinositol metabolic process	ISO	J:164563
Biological Process	GO:0030845	phospholipase C-inhibiting G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0070527	platelet aggregation	IMP	J:148429
Biological Process	GO:0032233	positive regulation of actin filament bundle assembly	ISO	J:164563
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	IMP	J:148429
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	ISO	J:164563
Biological Process	GO:0010925	positive regulation of inositol-polyphosphate 5-phosphatase activity	ISO	J:164563
Biological Process	GO:0033625	positive regulation of integrin activation	IMP	J:148429
Biological Process	GO:0010572	positive regulation of platelet activation	IMP	J:148429
Biological Process	GO:0070528	protein kinase C signaling	IMP	J:148429
Biological Process	GO:0070560	protein secretion by platelet	IMP	J:148429
Biological Process	GO:0060305	regulation of cell diameter	ISO	J:164563
Biological Process	GO:0031529	ruffle organization	ISO	J:164563
Biological Process	GO:0070493	thrombin-activated receptor signaling pathway	ISO	J:164563
Biological Process	GO:0070493	thrombin-activated receptor signaling pathway	IMP	J:148429
Biological Process	GO:0006904	vesicle docking involved in exocytosis	IMP	J:148429