GO Annotations Graph

• Symbol: Arhgef7
• Name: Rho guanine nucleotide exchange factor
• ID: MGI:1860493

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043015	gamma-tubulin binding	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IDA	J:182176
Molecular Function	GO:0005515	protein binding	IPI	J:141061
Molecular Function	GO:0005515	protein binding	IPI	J:83580
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:189982
Molecular Function	GO:0005515	protein binding	IPI	J:175149
Molecular Function	GO:0005515	protein binding	IPI	J:203427
Molecular Function	GO:0005515	protein binding	IPI	J:177237
Molecular Function	GO:0005515	protein binding	IPI	J:56615
Molecular Function	GO:0005515	protein binding	IPI	J:182176
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	IPI	J:183203
Molecular Function	GO:0031267	small GTPase binding	ISO	J:155856
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:182176
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0030027	lamellipodium	IDA	J:189982
Cellular Component	GO:0030027	lamellipodium	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0097431	mitotic spindle pole	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:182176
Cellular Component	GO:0098794	postsynapse	IDA	J:205503
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0000322	storage vacuole	IDA	J:182176
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0043615	astrocyte cell migration	ISO	J:155856
Biological Process	GO:0007030	Golgi organization	ISO	J:164563
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	IGI	J:202604
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0030032	lamellipodium assembly	IMP	J:189982
Biological Process	GO:0030032	lamellipodium assembly	IBA	J:265628
Biological Process	GO:1905833	negative regulation of microtubule nucleation	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0060124	positive regulation of growth hormone secretion	IMP	J:182176
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	HMP	J:212793
Biological Process	GO:0043547	positive regulation of GTPase activity	IMP	J:182176
Biological Process	GO:0032092	positive regulation of protein binding	IMP	J:182176
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	ISO	J:155856
Biological Process	GO:0099140	presynaptic actin cytoskeleton organization	ISO	J:155856
Biological Process	GO:1904424	regulation of GTP binding	ISO	J:164563
Biological Process	GO:0007264	small GTPase mediated signal transduction	ISO	J:155856