GO Annotations Graph

• Symbol: Pde3a
• Name: phosphodiesterase 3A, cGMP inhibited
• ID: MGI:1860764

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IBA	J:265628
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IDA	J:70210
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0004119	cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0099130	estrogen binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0030284	nuclear estrogen receptor activity	ISO	J:164563
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:210072
Cellular Component	GO:0016020	membrane	IDA	J:210072
Biological Process	GO:0097190	apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0019933	cAMP-mediated signaling	ISO	J:164563
Biological Process	GO:0019933	cAMP-mediated signaling	IBA	J:265628
Biological Process	GO:0071321	cellular response to cGMP	ISO	J:164563
Biological Process	GO:0019934	cGMP-mediated signaling	ISO	J:164563
Biological Process	GO:0019934	cGMP-mediated signaling	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	ISO	J:164563
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	IBA	J:265628
Biological Process	GO:0043116	negative regulation of vascular permeability	ISO	J:164563
Biological Process	GO:0048599	oocyte development	IGI	J:153189
Biological Process	GO:0048599	oocyte development	IGI	J:153189
Biological Process	GO:0001556	oocyte maturation	IBA	J:265628
Biological Process	GO:0001556	oocyte maturation	IDA	J:70210
Biological Process	GO:0060282	positive regulation of oocyte development	IBA	J:265628
Biological Process	GO:0060282	positive regulation of oocyte development	IGI	J:153189
Biological Process	GO:0043117	positive regulation of vascular permeability	ISO	J:164563
Biological Process	GO:0040020	regulation of meiotic nuclear division	IDA	J:70210
Biological Process	GO:0060700	regulation of ribonuclease activity	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	IDA	J:70210
Biological Process	GO:0007165	signal transduction	IEA	J:72247