GO Annotations Graph

• Symbol: Ubr2
• Name: ubiquitin protein ligase E3 component n-recognin 2
• ID: MGI:1861099

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140852	histone ubiquitin ligase activity	IDA	J:157596
Molecular Function	GO:0070728	leucine binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:244182
Molecular Function	GO:0005515	protein binding	IPI	J:72859
Molecular Function	GO:0005515	protein binding	IPI	J:166982
Molecular Function	GO:0005515	protein binding	IPI	J:86438
Molecular Function	GO:0005515	protein binding	IPI	J:166982
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:306597
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IGI	J:72859
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:86438
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0000785	chromatin	IDA	J:157596
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0000151	ubiquitin ligase complex	IBA	J:265628
Cellular Component	GO:0000151	ubiquitin ligase complex	IGI	J:72859
Biological Process	GO:0071233	cellular response to leucine	ISO	J:164563
Biological Process	GO:0031507	heterochromatin formation	IDA	J:157596
Biological Process	GO:0033522	histone H2A ubiquitination	IBA	J:265628
Biological Process	GO:0007141	male meiosis I	IMP	J:86438
Biological Process	GO:0007140	male meiotic nuclear division	IMP	J:243410
Biological Process	GO:0032007	negative regulation of TOR signaling	ISO	J:164563
Biological Process	GO:0010529	negative regulation of transposition	IMP	J:244182
Biological Process	GO:0030163	protein catabolic process	IEA	J:72247
Biological Process	GO:0007131	reciprocal meiotic recombination	IMP	J:243410
Biological Process	GO:0007283	spermatogenesis	IMP	J:243410
Biological Process	GO:0007283	spermatogenesis	IMP	J:86438
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IDA	J:86438
Biological Process	GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway	IBA	J:265628