GO Annotations Graph

• Symbol: Fgf21
• Name: fibroblast growth factor 21
• ID: MGI:1861377

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-6784616
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IDA	J:284081
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0009887	animal organ morphogenesis	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ISO	J:155856
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:153198
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:153198
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:153198
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:181337
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IBA	J:265628
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:164563
Biological Process	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	IGI	J:153198
Biological Process	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	IGI	J:153198
Biological Process	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	IGI	J:153198
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IBA	J:265628
Biological Process	GO:0010898	positive regulation of triglyceride catabolic process	ISO	J:155856
Biological Process	GO:0030334	regulation of cell migration	IBA	J:265628