GO Annotations Graph

• Symbol: Sphk2
• Name: sphingosine kinase 2
• ID: MGI:1861380

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	ISO	J:164563
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	IDA	J:271700
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	IMP	J:120074
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	IBA	J:265628
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	IDA	J:62994
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	IMP	J:102911
Molecular Function	GO:0042393	histone binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:72247
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0001727	lipid kinase activity	IBA	J:265628
Molecular Function	GO:0003951	NAD+ kinase activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:273588
Molecular Function	GO:0005515	protein binding	IPI	J:148067
Molecular Function	GO:0008481	sphinganine kinase activity	ISO	J:164563
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:273514
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:62994
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:273514
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IBA	J:265628
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:62994
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:273588
Cellular Component	GO:0005739	mitochondrion	IDA	J:221807
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0000786	nucleosome	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:273588
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0001568	blood vessel development	IGI	J:103755
Biological Process	GO:0007420	brain development	IGI	J:103755
Biological Process	GO:0008283	cell population proliferation	IGI	J:103755
Biological Process	GO:1904628	cellular response to phorbol 13-acetate 12-myristate	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0046834	lipid phosphorylation	IMP	J:102911
Biological Process	GO:0030308	negative regulation of cell growth	IDA	J:273514
Biological Process	GO:0016310	phosphorylation	IBA	J:265628
Biological Process	GO:0043065	positive regulation of apoptotic process	IDA	J:273514
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0090280	positive regulation of calcium ion import	IMP	J:120074
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:103755
Biological Process	GO:2000304	positive regulation of ceramide biosynthetic process	ISO	J:164563
Biological Process	GO:2000304	positive regulation of ceramide biosynthetic process	IDA	J:273514
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	IMP	J:120074
Biological Process	GO:0032736	positive regulation of interleukin-13 production	IMP	J:120074
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:120074
Biological Process	GO:0033008	positive regulation of mast cell activation involved in immune response	IMP	J:120074
Biological Process	GO:0043306	positive regulation of mast cell degranulation	IMP	J:120074
Biological Process	GO:0090037	positive regulation of protein kinase C signaling	IMP	J:120074
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:120074
Biological Process	GO:2001169	regulation of ATP biosynthetic process	IMP	J:221807
Biological Process	GO:1904959	regulation of cytochrome-c oxidase activity	IMP	J:273588
Biological Process	GO:1904959	regulation of cytochrome-c oxidase activity	ISO	J:164563
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:120074
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	IMP	J:221807
Biological Process	GO:0006669	sphinganine-1-phosphate biosynthetic process	ISO	J:164563
Biological Process	GO:0006669	sphinganine-1-phosphate biosynthetic process	IDA	J:62994
Biological Process	GO:0006669	sphinganine-1-phosphate biosynthetic process	IBA	J:265628
Biological Process	GO:0046512	sphingosine biosynthetic process	ISO	J:164563
Biological Process	GO:0046512	sphingosine biosynthetic process	IBA	J:265628
Biological Process	GO:0006670	sphingosine metabolic process	IMP	J:120074
Biological Process	GO:0006670	sphingosine metabolic process	IMP	J:102911
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling	ISO	J:164563