GO Annotations Graph

• Symbol: Espn
• Name: espin
• ID: MGI:1861630

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:72247
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0051015	actin filament binding	ISO	J:155856
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:236347
Molecular Function	GO:0005515	protein binding	IPI	J:182310
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:155856
Cellular Component	GO:0015629	actin cytoskeleton	IDA	J:58991
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:73065
Cellular Component	GO:0005903	brush border	IDA	J:219622
Cellular Component	GO:0005903	brush border	ISO	J:155856
Cellular Component	GO:0005903	brush border	TAS	J:53411
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9659536
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9663360
Cellular Component	GO:0031941	filamentous actin	ISO	J:155856
Cellular Component	GO:0005902	microvillus	ISO	J:164563
Cellular Component	GO:0005902	microvillus	ISO	J:73065
Cellular Component	GO:0032420	stereocilium	ISO	J:164563
Cellular Component	GO:0032420	stereocilium	IDA	J:167947
Cellular Component	GO:0032421	stereocilium bundle	IDA	J:157099
Cellular Component	GO:0032426	stereocilium tip	IDA	J:230827
Cellular Component	GO:0032426	stereocilium tip	EXP	J:230827
Cellular Component	GO:0032426	stereocilium tip	IDA	J:182310
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0051017	actin filament bundle assembly	IBA	J:265628
Biological Process	GO:0051017	actin filament bundle assembly	IDA	J:58991
Biological Process	GO:0051639	actin filament network formation	NAS	J:114145
Biological Process	GO:0007626	locomotory behavior	IMP	J:113021
Biological Process	GO:0030034	microvillar actin bundle assembly	ISO	J:164563
Biological Process	GO:0051494	negative regulation of cytoskeleton organization	IDA	J:114105
Biological Process	GO:0030046	parallel actin filament bundle assembly	IDA	J:58991
Biological Process	GO:0051491	positive regulation of filopodium assembly	IGI	J:182310
Biological Process	GO:0051491	positive regulation of filopodium assembly	IPI	J:182310
Biological Process	GO:0007605	sensory perception of sound	IEA	J:60000