GO Annotations Graph

• Symbol: Brd4
• Name: bromodomain containing 4
• ID: MGI:1888520

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:199171
Molecular Function	GO:0003682	chromatin binding	IDA	J:191206
Molecular Function	GO:0003677	DNA binding	IDA	J:101015
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0034211	GTP-dependent protein kinase activity	IDA	J:183914
Molecular Function	GO:0140566	histone reader activity	ISO	J:164563
Molecular Function	GO:0070577	lysine-acetylated histone binding	ISO	J:164563
Molecular Function	GO:0070577	lysine-acetylated histone binding	ISO	J:164563
Molecular Function	GO:0070577	lysine-acetylated histone binding	IBA	J:265628
Molecular Function	GO:0106140	P-TEFb complex binding	ISO	J:164563
Molecular Function	GO:0106140	P-TEFb complex binding	ISO	J:164563
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:145726
Molecular Function	GO:0005515	protein binding	IPI	J:191206
Molecular Function	GO:0005515	protein binding	IPI	J:101015
Molecular Function	GO:0005515	protein binding	IPI	J:101015
Molecular Function	GO:0005515	protein binding	IPI	J:101015
Molecular Function	GO:0005515	protein binding	IPI	J:101015
Molecular Function	GO:0005515	protein binding	IPI	J:199171
Molecular Function	GO:0005515	protein binding	IPI	J:101015
Molecular Function	GO:0005515	protein binding	IPI	J:191206
Molecular Function	GO:0005515	protein binding	IPI	J:101015
Molecular Function	GO:0099122	RNA polymerase II C-terminal domain binding	IPI	J:183914
Molecular Function	GO:0099122	RNA polymerase II C-terminal domain binding	ISO	J:73065
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	IMP	J:183914
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	ISO	J:73065
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	IDA	J:183914
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:164563
Molecular Function	GO:0003712	transcription coregulator activity	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IBA	J:265628
Cellular Component	GO:0000785	chromatin	IDA	J:111726
Cellular Component	GO:0005694	chromosome	ISO	J:164563
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:130392
Cellular Component	GO:0000794	condensed nuclear chromosome	ISO	J:73065
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:63928
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:111726
Cellular Component	GO:0008024	cyclin/CDK positive transcription elongation factor complex	IDA	J:199171
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:63928
Cellular Component	GO:0005634	nucleus	IDA	J:101015
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006338	chromatin remodeling	ISO	J:164563
Biological Process	GO:0006338	chromatin remodeling	IBA	J:265628
Biological Process	GO:0007059	chromosome segregation	IMP	J:111726
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0001833	inner cell mass cell proliferation	IMP	J:76662
Biological Process	GO:0043922	negative regulation by host of viral transcription	ISO	J:164563
Biological Process	GO:2000002	negative regulation of DNA damage checkpoint	ISO	J:164563
Biological Process	GO:0043388	positive regulation of DNA binding	IDA	J:101015
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	ISO	J:73065
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	ISO	J:73065
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:183914
Biological Process	GO:0006468	protein phosphorylation	IPI	J:101015
Biological Process	GO:0006468	protein phosphorylation	IPI	J:101015
Biological Process	GO:0006355	regulation of DNA-templated transcription	IBA	J:265628
Biological Process	GO:0050727	regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	ISO	J:73065