GO Annotations Graph

• Symbol: Tbx21
• Name: T-box 21
• ID: MGI:1888984

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IMP	J:204781
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:61321
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IEA	J:72247
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:185377
Molecular Function	GO:0005515	protein binding	IPI	J:167439
Molecular Function	GO:0005515	protein binding	IPI	J:167439
Molecular Function	GO:0005515	protein binding	IPI	J:175086
Molecular Function	GO:0005515	protein binding	IPI	J:166998
Molecular Function	GO:0005515	protein binding	IPI	J:245321
Molecular Function	GO:0005515	protein binding	IPI	J:204781
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	IDA	J:96969
Cellular Component	GO:0005634	nucleus	IDA	J:175086
Cellular Component	GO:0005634	nucleus	IDA	J:204781
Cellular Component	GO:0005634	nucleus	IDA	J:245321
Cellular Component	GO:0005634	nucleus	IDA	J:174520
Biological Process	GO:0001708	cell fate specification	IBA	J:265628
Biological Process	GO:0071310	cellular response to organic substance	IDA	J:174553
Biological Process	GO:0072676	lymphocyte migration	IMP	J:153703
Biological Process	GO:0072676	lymphocyte migration	ISO	J:164563
Biological Process	GO:0072676	lymphocyte migration	IBA	J:265628
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:245321
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:204781
Biological Process	GO:0032703	negative regulation of interleukin-2 production	IMP	J:204781
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	IDA	J:167439
Biological Process	GO:2000329	negative regulation of T-helper 17 cell lineage commitment	IMP	J:167439
Biological Process	GO:2000552	negative regulation of T-helper 2 cell cytokine production	IMP	J:204781
Biological Process	GO:2000552	negative regulation of T-helper 2 cell cytokine production	IDA	J:61321
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:153703
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:204781
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:175086
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:245321
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:189858
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	IMP	J:84929
Biological Process	GO:2000556	positive regulation of T-helper 1 cell cytokine production	IDA	J:61321
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:61321
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	J:204781
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0050776	regulation of immune response	IMP	J:84929
Biological Process	GO:0045580	regulation of T cell differentiation	IMP	J:175086
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0030217	T cell differentiation	IMP	J:160369
Biological Process	GO:0002296	T-helper 1 cell lineage commitment	IDA	J:61321