GO Annotations Graph

• Symbol: Gsdme
• Name: gasdermin E
• ID: MGI:1889850

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:1901612	cardiolipin binding	IDA	J:250434
Molecular Function	GO:1901612	cardiolipin binding	ISO	J:164563
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0022829	wide pore channel activity	ISO	J:164563
Molecular Function	GO:0022829	wide pore channel activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:240546
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0008219	cell death	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0098586	cellular response to virus	IMP	J:241308
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0140507	granzyme-mediated programmed cell death signaling pathway	ISO	J:164563
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	IMP	J:99624
Biological Process	GO:0070265	necrotic cell death	IMP	J:241308
Biological Process	GO:0070265	necrotic cell death	ISO	J:164563
Biological Process	GO:0070265	necrotic cell death	IBA	J:265628
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0002839	positive regulation of immune response to tumor cell	ISO	J:164563
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0012501	programmed cell death	IEA	J:60000
Biological Process	GO:0070269	pyroptosis	ISO	J:164563
Biological Process	GO:0070269	pyroptosis	ISO	J:164563
Biological Process	GO:0007605	sensory perception of sound	ISO	J:50172