GO Annotations Graph

• Symbol: Foxo1
• Name: forkhead box O1
• ID: MGI:1890077

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:270723
Molecular Function	GO:0003677	DNA binding	IDA	J:80826
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:117723
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:287060
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:270723
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:80826
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:254113
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:79560
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:127427
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IGI	J:154024
Molecular Function	GO:0003676	nucleic acid binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:184441
Molecular Function	GO:0005515	protein binding	IPI	J:114687
Molecular Function	GO:0005515	protein binding	IPI	J:139427
Molecular Function	GO:0005515	protein binding	IPI	J:209483
Molecular Function	GO:0005515	protein binding	IPI	J:124079
Molecular Function	GO:0005515	protein binding	IPI	J:224726
Molecular Function	GO:0005515	protein binding	IPI	J:186018
Molecular Function	GO:0005515	protein binding	IPI	J:184684
Molecular Function	GO:0005515	protein binding	IPI	J:225490
Molecular Function	GO:0005515	protein binding	IPI	J:184684
Molecular Function	GO:0005515	protein binding	IPI	J:245577
Molecular Function	GO:0005515	protein binding	IPI	J:199282
Molecular Function	GO:0005515	protein binding	IPI	J:184441
Molecular Function	GO:0005515	protein binding	IPI	J:184441
Molecular Function	GO:0051721	protein phosphatase 2A binding	IDA	J:185464
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:117723
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:69574
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:155856
Molecular Function	GO:0008134	transcription factor binding	IPI	J:117723
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:129943
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:225490
Cellular Component	GO:0005737	cytoplasm	IDA	J:209483
Cellular Component	GO:0005737	cytoplasm	IDA	J:287060
Cellular Component	GO:0005737	cytoplasm	IDA	J:254113
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:170486
Cellular Component	GO:0005737	cytoplasm	IDA	J:80826
Cellular Component	GO:0005737	cytoplasm	IDA	J:85536
Cellular Component	GO:0005737	cytoplasm	IDA	J:100095
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9623032
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9623061
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9623231
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9623232
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9623284
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9625109
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9625402
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9625700
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9625830
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9626966
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9626944
Cellular Component	GO:0005634	nucleus	IDA	J:129943
Cellular Component	GO:0005634	nucleus	IDA	J:209483
Cellular Component	GO:0005634	nucleus	IDA	J:225490
Cellular Component	GO:0005634	nucleus	IDA	J:170486
Cellular Component	GO:0005634	nucleus	IDA	J:287060
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:245577
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:254113
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:184441
Cellular Component	GO:0005634	nucleus	IDA	J:180723
Cellular Component	GO:0005634	nucleus	IDA	J:85536
Cellular Component	GO:0005634	nucleus	IDA	J:100095
Cellular Component	GO:0005634	nucleus	IDA	J:199282
Cellular Component	GO:0005634	nucleus	IDA	J:80826
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0001568	blood vessel development	IMP	J:92247
Biological Process	GO:0001568	blood vessel development	IMP	J:88638
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0071455	cellular response to hyperoxia	ISO	J:164563
Biological Process	GO:0032869	cellular response to insulin stimulus	IDA	J:129943
Biological Process	GO:0071732	cellular response to nitric oxide	IDA	J:187559
Biological Process	GO:0034599	cellular response to oxidative stress	IDA	J:185464
Biological Process	GO:0009267	cellular response to starvation	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IDA	J:187559
Biological Process	GO:0042593	glucose homeostasis	IDA	J:170486
Biological Process	GO:0008286	insulin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:80826
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	ISO	J:155856
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IMP	J:129943
Biological Process	GO:0046676	negative regulation of insulin secretion	IDA	J:254113
Biological Process	GO:0046676	negative regulation of insulin secretion	IDA	J:79560
Biological Process	GO:0032873	negative regulation of stress-activated MAPK cascade	ISO	J:164563
Biological Process	GO:0097150	neuronal stem cell population maintenance	IGI	J:154024
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:270723
Biological Process	GO:0045722	positive regulation of gluconeogenesis	ISO	J:164563
Biological Process	GO:0045722	positive regulation of gluconeogenesis	IMP	J:160664
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:160664
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:122746
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:80826
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:80826
Biological Process	GO:0006111	regulation of gluconeogenesis	IMP	J:137715
Biological Process	GO:2000177	regulation of neural precursor cell proliferation	IGI	J:154024
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	IGI	J:154024
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:117723
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0070542	response to fatty acid	IDA	J:287060