GO Annotations Graph

• Symbol: Foxo3
• Name: forkhead box O3
• ID: MGI:1890081

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:210910
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:93432
Molecular Function	GO:0003677	DNA binding	IDA	J:88189
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:168129
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:287060
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:130442
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:130403
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:73065
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:88189
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:92432
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IGI	J:154024
Molecular Function	GO:0034246	mitochondrial transcription factor activity	IMP	J:257325
Molecular Function	GO:0034246	mitochondrial transcription factor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:210910
Molecular Function	GO:0005515	protein binding	IPI	J:257325
Molecular Function	GO:0005515	protein binding	IPI	J:200481
Molecular Function	GO:0005515	protein binding	IPI	J:184684
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:210910
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:69574
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:168129
Molecular Function	GO:0001221	transcription coregulator binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:257325
Cellular Component	GO:0005737	cytoplasm	IDA	J:287060
Cellular Component	GO:0005737	cytoplasm	IDA	J:88189
Cellular Component	GO:0005737	cytoplasm	IDA	J:93432
Cellular Component	GO:0005737	cytoplasm	IDA	J:85536
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:130442
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:93432
Cellular Component	GO:0005759	mitochondrial matrix	IDA	J:257318
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	IBA	J:265628
Cellular Component	GO:0005741	mitochondrial outer membrane	IDA	J:257318
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:257325
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9622792
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9625402
Cellular Component	GO:0005634	nucleus	IDA	J:130442
Cellular Component	GO:0005634	nucleus	IDA	J:257325
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:287060
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:85536
Cellular Component	GO:0005634	nucleus	ISO	J:217701
Cellular Component	GO:0005634	nucleus	IDA	J:88189
Cellular Component	GO:0032991	protein-containing complex	IDA	J:257325
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0090571	RNA polymerase II transcription repressor complex	ISO	J:164563
Biological Process	GO:0007568	aging	ISO	J:155856
Biological Process	GO:0001547	antral ovarian follicle growth	IMP	J:88638
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0048854	brain morphogenesis	IGI	J:226736
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0034599	cellular response to oxidative stress	IDA	J:210910
Biological Process	GO:0034599	cellular response to oxidative stress	IGI	J:226736
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	IDA	J:93432
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IGI	J:88139
Biological Process	GO:0042593	glucose homeostasis	IMP	J:84269
Biological Process	GO:0001544	initiation of primordial ovarian follicle growth	IMP	J:84269
Biological Process	GO:0006390	mitochondrial transcription	IMP	J:257325
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0045665	negative regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:243395
Biological Process	GO:0097150	neuronal stem cell population maintenance	IGI	J:226736
Biological Process	GO:0097150	neuronal stem cell population maintenance	IGI	J:226736
Biological Process	GO:0097150	neuronal stem cell population maintenance	IGI	J:154024
Biological Process	GO:0001556	oocyte maturation	IMP	J:84269
Biological Process	GO:0001542	ovulation from ovarian follicle	IMP	J:84269
Biological Process	GO:0010508	positive regulation of autophagy	IDA	J:130403
Biological Process	GO:0010508	positive regulation of autophagy	IDA	J:130442
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:130442
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:130403
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:78043
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	ISO	J:155856
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	ISO	J:73065
Biological Process	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death	ISO	J:155856
Biological Process	GO:1902895	positive regulation of miRNA transcription	IMP	J:168129
Biological Process	GO:0014737	positive regulation of muscle atrophy	IDA	J:130403
Biological Process	GO:0014737	positive regulation of muscle atrophy	IDA	J:130442
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:88198
Biological Process	GO:2000177	regulation of neural precursor cell proliferation	IGI	J:154024
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	IGI	J:154024
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:210910
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0070542	response to fatty acid	IDA	J:287060
Biological Process	GO:0042594	response to starvation	IDA	J:130403
Biological Process	GO:0042594	response to starvation	IDA	J:130442