GO Annotations Graph

• Symbol: Rad18
• Name: RAD18 E3 ubiquitin protein ligase
• ID: MGI:1890476

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:215791
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:81138
Molecular Function	GO:0005515	protein binding	IPI	J:81138
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0003697	single-stranded DNA binding	IEA	J:72247
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IEA	J:72247
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0000403	Y-form DNA binding	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:95995
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:145534
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0042405	nuclear inclusion body	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:215791
Cellular Component	GO:0005634	nucleus	IDA	J:65085
Cellular Component	GO:0097505	Rad6-Rad18 complex	IBA	J:265628
Cellular Component	GO:0005657	replication fork	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Cellular Component	GO:0001741	XY body	IDA	J:92954
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:215791
Biological Process	GO:0006974	DNA damage response	IMP	J:81138
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:72247
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:164563
Biological Process	GO:0045910	negative regulation of DNA recombination	IMP	J:81138
Biological Process	GO:0051984	positive regulation of chromosome segregation	ISO	J:164563
Biological Process	GO:0006301	postreplication repair	IBA	J:265628
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:215791
Biological Process	GO:0006513	protein monoubiquitination	IBA	J:265628
Biological Process	GO:0009411	response to UV	IMP	J:81138
Biological Process	GO:0007283	spermatogenesis	IMP	J:145534