GO Annotations Graph

• Symbol: Nherf2
• Name: NHERF family PDZ scaffold protein 2
• ID: MGI:1890662

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:155856
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:155856
Molecular Function	GO:0019902	phosphatase binding	IPI	J:105981
Molecular Function	GO:0019902	phosphatase binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:115432
Molecular Function	GO:0005515	protein binding	IPI	J:105981
Molecular Function	GO:0005515	protein binding	IPI	J:105981
Molecular Function	GO:0005515	protein binding	IPI	J:75423
Molecular Function	GO:0043495	protein-membrane adaptor activity	IBA	J:265628
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	IBA	J:265628
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:78606
Cellular Component	GO:0005737	cytoplasm	IDA	J:75423
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:75423
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032420	stereocilium	IDA	J:212101
Cellular Component	GO:0032420	stereocilium	IDA	J:212101
Cellular Component	GO:0032421	stereocilium bundle	IDA	J:212101
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	IGI	J:105981
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IGI	J:105981
Biological Process	GO:0034767	positive regulation of monoatomic ion transmembrane transport	ISO	J:155856
Biological Process	GO:0072659	protein localization to plasma membrane	IBA	J:265628
Biological Process	GO:0007605	sensory perception of sound	IMP	J:212101