GO Annotations Graph

• Symbol: Actn4
• Name: actinin alpha 4
• ID: MGI:1890773

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0051015	actin filament binding	IDA	J:136002
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0051015	actin filament binding	IDA	J:93130
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016922	nuclear receptor binding	ISO	J:164563
Molecular Function	GO:0030374	nuclear receptor coactivator activity	ISO	J:164563
Molecular Function	GO:0042974	nuclear retinoic acid receptor binding	ISO	J:164563
Molecular Function	GO:0001882	nucleoside binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:117470
Molecular Function	GO:0005515	protein binding	IPI	J:306605
Molecular Function	GO:0005515	protein binding	IPI	J:136002
Molecular Function	GO:0005515	protein binding	IPI	J:201396
Molecular Function	GO:0005515	protein binding	IPI	J:221512
Molecular Function	GO:0005515	protein binding	IPI	J:187422
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0005515	protein binding	IPI	J:85387
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0005200	structural constituent of cytoskeleton	IMP	J:115805
Molecular Function	GO:0005200	structural constituent of cytoskeleton	IMP	J:83911
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:155856
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IBA	J:265628
Cellular Component	GO:0042995	cell projection	IBA	J:265628
Cellular Component	GO:0005911	cell-cell junction	IDA	J:136002
Cellular Component	GO:0030864	cortical actin cytoskeleton	IDA	J:115805
Cellular Component	GO:0030864	cortical actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0030863	cortical cytoskeleton	IDA	J:85387
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:85387
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005925	focal adhesion	IDA	J:115805
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:306605
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0031143	pseudopodium	IDA	J:114115
Cellular Component	GO:1990904	ribonucleoprotein complex	ISO	J:164563
Cellular Component	GO:0001725	stress fiber	IDA	J:201396
Cellular Component	GO:0001725	stress fiber	ISO	J:155856
Cellular Component	GO:0001725	stress fiber	IDA	J:98090
Cellular Component	GO:0030018	Z disc	IBA	J:265628
Cellular Component	GO:0030018	Z disc	IDA	J:158675
Cellular Component	GO:0030018	Z disc	IDA	J:158797
Biological Process	GO:0030036	actin cytoskeleton organization	IBA	J:265628
Biological Process	GO:0051017	actin filament bundle assembly	IDA	J:98090
Biological Process	GO:0070830	bicellular tight junction assembly	IMP	J:136002
Biological Process	GO:0032835	glomerulus development	IDA	J:83911
Biological Process	GO:0055001	muscle cell development	IBA	J:265628
Biological Process	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0035357	peroxisome proliferator activated receptor signaling pathway	ISO	J:164563
Biological Process	GO:0090521	podocyte cell migration	IMP	J:115805
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0048549	positive regulation of pinocytosis	IMP	J:113905
Biological Process	GO:1902396	protein localization to bicellular tight junction	IMP	J:136002
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:155856
Biological Process	GO:1903506	regulation of nucleic acid-templated transcription	ISO	J:164563
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	ISO	J:164563
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0030050	vesicle transport along actin filament	ISO	J:164563