GO Annotations Graph

• Symbol: F12
• Name: coagulation factor XII (Hageman factor)
• ID: MGI:1891012

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IMP	J:124154
Molecular Function	GO:0004252	serine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004252	serine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IMP	J:124154
Cellular Component	GO:0005791	rough endoplasmic reticulum	IBA	J:265628
Biological Process	GO:0007596	blood coagulation	ISO	J:155856
Biological Process	GO:0007596	blood coagulation	IBA	J:265628
Biological Process	GO:0007596	blood coagulation	IMP	J:124154
Biological Process	GO:0002542	Factor XII activation	ISO	J:164563
Biological Process	GO:0042730	fibrinolysis	IEA	J:60000
Biological Process	GO:0007599	hemostasis	IEA	J:60000
Biological Process	GO:0002353	plasma kallikrein-kinin cascade	ISO	J:164563
Biological Process	GO:0030194	positive regulation of blood coagulation	ISO	J:164563
Biological Process	GO:0051919	positive regulation of fibrinolysis	ISO	J:164563
Biological Process	GO:0010756	positive regulation of plasminogen activation	ISO	J:164563
Biological Process	GO:0016540	protein autoprocessing	ISO	J:164563
Biological Process	GO:0016485	protein processing	ISO	J:164563
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0051788	response to misfolded protein	ISO	J:164563
Biological Process	GO:0031638	zymogen activation	ISO	J:164563
Biological Process	GO:0031638	zymogen activation	IBA	J:265628