GO Annotations Graph

• Symbol: Mtrr
• Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
• ID: MGI:1891037

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030586	[methionine synthase] reductase activity	IBA	J:265628
Molecular Function	GO:0030586	[methionine synthase] reductase activity	IMP	J:121477
Molecular Function	GO:0030586	[methionine synthase] reductase activity	ISO	J:319904
Molecular Function	GO:0030586	[methionine synthase] reductase activity	ISO	J:73065
Molecular Function	GO:0030586	[methionine synthase] reductase activity	ISO	J:73065
Molecular Function	GO:0071949	FAD binding	ISO	J:164563
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	ISO	J:164563
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	IBA	J:265628
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	ISO	J:73065
Molecular Function	GO:0010181	FMN binding	ISO	J:164563
Molecular Function	GO:0010181	FMN binding	IBA	J:265628
Molecular Function	GO:0010181	FMN binding	ISO	J:73065
Molecular Function	GO:0070402	NADPH binding	ISO	J:164563
Molecular Function	GO:0003958	NADPH-hemoprotein reductase activity	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016723	oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:312343
Cellular Component	GO:0045111	intermediate filament cytoskeleton	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Biological Process	GO:0008652	amino acid biosynthetic process	IEA	J:60000
Biological Process	GO:0009235	cobalamin metabolic process	IMP	J:121477
Biological Process	GO:0006306	DNA methylation	IMP	J:201187
Biological Process	GO:0046655	folic acid metabolic process	ISO	J:164563
Biological Process	GO:0046655	folic acid metabolic process	IMP	J:201187
Biological Process	GO:0043418	homocysteine catabolic process	ISO	J:164563
Biological Process	GO:0050667	homocysteine metabolic process	IMP	J:121477
Biological Process	GO:0050667	homocysteine metabolic process	IBA	J:265628
Biological Process	GO:0009086	methionine biosynthetic process	IMP	J:121477
Biological Process	GO:0009086	methionine biosynthetic process	ISO	J:164563
Biological Process	GO:0009086	methionine biosynthetic process	IBA	J:265628
Biological Process	GO:1904042	negative regulation of cystathionine beta-synthase activity	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:73065
Biological Process	GO:0050821	protein stabilization	ISO	J:73065
Biological Process	GO:0033353	S-adenosylmethionine cycle	IMP	J:121477