GO Annotations Graph

• Symbol: Kcne2
• Name: potassium voltage-gated channel, Isk-related subfamily, gene 2
• ID: MGI:1891123

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	ISO	J:164563
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	ISO	J:155856
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005242	inward rectifier potassium channel activity	ISO	J:155856
Molecular Function	GO:0005242	inward rectifier potassium channel activity	ISO	J:164563
Molecular Function	GO:0005267	potassium channel activity	IEA	J:60000
Molecular Function	GO:0015459	potassium channel regulator activity	ISO	J:155856
Molecular Function	GO:0015459	potassium channel regulator activity	ISO	J:164563
Molecular Function	GO:0015459	potassium channel regulator activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:258659
Molecular Function	GO:0005515	protein binding	IPI	J:258659
Molecular Function	GO:0005515	protein binding	IPI	J:140247
Molecular Function	GO:0005515	protein binding	IPI	J:140247
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	IBA	J:265628
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Molecular Function	GO:0005249	voltage-gated potassium channel activity	ISO	J:155856
Molecular Function	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	ISO	J:164563
Molecular Function	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IBA	J:265628
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:258659
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:140247
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0008076	voltage-gated potassium channel complex	ISO	J:155856
Cellular Component	GO:0008076	voltage-gated potassium channel complex	ISO	J:164563
Cellular Component	GO:0008076	voltage-gated potassium channel complex	ISO	J:164563
Cellular Component	GO:0008076	voltage-gated potassium channel complex	IDA	J:258659
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	ISO	J:164563
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	ISO	J:164563
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:140247
Biological Process	GO:0015705	iodide transport	IMP	J:187467
Biological Process	GO:0086009	membrane repolarization	ISO	J:164563
Biological Process	GO:0086009	membrane repolarization	ISO	J:155856
Biological Process	GO:0086011	membrane repolarization during action potential	ISO	J:155856
Biological Process	GO:0086011	membrane repolarization during action potential	ISO	J:164563
Biological Process	GO:0086011	membrane repolarization during action potential	IBA	J:265628
Biological Process	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0033555	multicellular organismal response to stress	IMP	J:258659
Biological Process	GO:0015798	myo-inositol transport	IMP	J:258659
Biological Process	GO:1902260	negative regulation of delayed rectifier potassium channel activity	ISO	J:155856
Biological Process	GO:1902260	negative regulation of delayed rectifier potassium channel activity	ISO	J:164563
Biological Process	GO:1902260	negative regulation of delayed rectifier potassium channel activity	IBA	J:265628
Biological Process	GO:1903817	negative regulation of voltage-gated potassium channel activity	ISO	J:155856
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	ISO	J:164563
Biological Process	GO:1901387	positive regulation of voltage-gated calcium channel activity	ISO	J:155856
Biological Process	GO:0097623	potassium ion export across plasma membrane	ISO	J:164563
Biological Process	GO:0097623	potassium ion export across plasma membrane	ISO	J:155856
Biological Process	GO:0097623	potassium ion export across plasma membrane	IBA	J:265628
Biological Process	GO:1990573	potassium ion import across plasma membrane	ISO	J:164563
Biological Process	GO:1990573	potassium ion import across plasma membrane	ISO	J:155856
Biological Process	GO:0071805	potassium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0071805	potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0071805	potassium ion transmembrane transport	IMP	J:140247
Biological Process	GO:0006813	potassium ion transport	IEA	J:72247
Biological Process	GO:0006813	potassium ion transport	IEA	J:60000
Biological Process	GO:0008104	protein localization	IMP	J:140247
Biological Process	GO:1902159	regulation of cyclic nucleotide-gated ion channel activity	ISO	J:155856
Biological Process	GO:1902259	regulation of delayed rectifier potassium channel activity	ISO	J:155856
Biological Process	GO:1902259	regulation of delayed rectifier potassium channel activity	ISO	J:164563
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ISO	J:164563
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IBA	J:265628
Biological Process	GO:1901979	regulation of inward rectifier potassium channel activity	ISO	J:155856
Biological Process	GO:1901979	regulation of inward rectifier potassium channel activity	ISO	J:164563
Biological Process	GO:0060306	regulation of membrane repolarization	ISO	J:155856
Biological Process	GO:0060306	regulation of membrane repolarization	ISO	J:164563
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:1901379	regulation of potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:1901379	regulation of potassium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	ISO	J:164563
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	IBA	J:265628
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	IMP	J:140247
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	IBA	J:265628
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	IMP	J:140247