GO Annotations Graph

• Symbol: Efemp2
• Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 2
• ID: MGI:1891209

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0030023	extracellular matrix constituent conferring elasticity	RCA	J:265604
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:221200
Molecular Function	GO:0005515	protein binding	IPI	J:121136
Molecular Function	GO:0005515	protein binding	IPI	J:226034
Molecular Function	GO:0005515	protein binding	IPI	J:297323
Molecular Function	GO:0005515	protein binding	IPI	J:106902
Molecular Function	GO:0005515	protein binding	IPI	J:154659
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Cellular Component	GO:0005604	basement membrane	IDA	J:121136
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0071953	elastic fiber	IMP	J:106902
Cellular Component	GO:0071953	elastic fiber	ISO	J:164563
Cellular Component	GO:0031012	extracellular matrix	IDA	J:232351
Cellular Component	GO:0031012	extracellular matrix	IDA	J:121136
Cellular Component	GO:0031012	extracellular matrix	ISO	J:164563
Cellular Component	GO:0031012	extracellular matrix	TAS	J:60560
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0001527	microfibril	IDA	J:121136
Biological Process	GO:0035904	aorta development	IMP	J:170883
Biological Process	GO:0060414	aorta smooth muscle tissue morphogenesis	IMP	J:261872
Biological Process	GO:0060414	aorta smooth muscle tissue morphogenesis	IMP	J:223792
Biological Process	GO:0060840	artery development	IMP	J:154659
Biological Process	GO:0048251	elastic fiber assembly	IMP	J:106902
Biological Process	GO:0048251	elastic fiber assembly	IMP	J:223792
Biological Process	GO:0048251	elastic fiber assembly	IMP	J:261872
Biological Process	GO:0048251	elastic fiber assembly	IMP	J:170883
Biological Process	GO:0048251	elastic fiber assembly	ISO	J:164563
Biological Process	GO:0048251	elastic fiber assembly	IMP	J:258180
Biological Process	GO:0048251	elastic fiber assembly	IMP	J:154659
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	IMP	J:213282
Biological Process	GO:1904831	positive regulation of aortic smooth muscle cell differentiation	IMP	J:170883
Biological Process	GO:1904028	positive regulation of collagen fibril organization	IMP	J:226034
Biological Process	GO:1904028	positive regulation of collagen fibril organization	IMP	J:223792
Biological Process	GO:1904028	positive regulation of collagen fibril organization	IMP	J:261872
Biological Process	GO:1905609	positive regulation of smooth muscle cell-matrix adhesion	ISO	J:164563
Biological Process	GO:1904026	regulation of collagen fibril organization	IMP	J:232351
Biological Process	GO:0097084	vascular associated smooth muscle cell development	IMP	J:213282