GO Annotations Graph

• Symbol: Foxp3
• Name: forkhead box P3
• ID: MGI:1891436

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:117627
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:117627
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:117627
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:117627
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:117627
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:117627
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0035035	histone acetyltransferase binding	ISO	J:164563
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:116306
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0051525	NFAT protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:297332
Molecular Function	GO:0005515	protein binding	IPI	J:121433
Molecular Function	GO:0005515	protein binding	IPI	J:121433
Molecular Function	GO:0005515	protein binding	IPI	J:121433
Molecular Function	GO:0005515	protein binding	IPI	J:136164
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:121433
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:117627
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:117627
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:117627
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:117627
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:117627
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0003714	transcription corepressor activity	IDA	J:97353
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:117627
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:141377
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:136164
Cellular Component	GO:0005634	nucleus	IDA	J:121433
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:117627
Cellular Component	GO:0005634	nucleus	IDA	J:116306
Biological Process	GO:0046633	alpha-beta T cell proliferation	IMP	J:115967
Biological Process	GO:0001782	B cell homeostasis	IMP	J:53219
Biological Process	GO:0043367	CD4-positive, alpha-beta T cell differentiation	IDA	J:117627
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	IDA	J:117627
Biological Process	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP	J:137389
Biological Process	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP	J:117165
Biological Process	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP	J:118845
Biological Process	GO:0002362	CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment	TAS	J:136164
Biological Process	GO:0006338	chromatin remodeling	IDA	J:117627
Biological Process	GO:0001816	cytokine production	IDA	J:97353
Biological Process	GO:0001816	cytokine production	IMP	J:53219
Biological Process	GO:0001816	cytokine production	IGI	J:20865
Biological Process	GO:0001816	cytokine production	IMP	J:20865
Biological Process	GO:0001816	cytokine production	IMP	J:33090
Biological Process	GO:0006351	DNA-templated transcription	IDA	J:117627
Biological Process	GO:0010467	gene expression	IMP	J:241346
Biological Process	GO:0033080	immature T cell proliferation in thymus	IMP	J:116829
Biological Process	GO:0006954	inflammatory response	IMP	J:102496
Biological Process	GO:0006954	inflammatory response	IMP	J:102496
Biological Process	GO:0032613	interleukin-10 production	IMP	J:117165
Biological Process	GO:0032623	interleukin-2 production	IDA	J:117627
Biological Process	GO:0032623	interleukin-2 production	IDA	J:116306
Biological Process	GO:0032633	interleukin-4 production	IMP	J:117165
Biological Process	GO:0032633	interleukin-4 production	IDA	J:116306
Biological Process	GO:0032634	interleukin-5 production	IMP	J:117165
Biological Process	GO:0032634	interleukin-5 production	IDA	J:116306
Biological Process	GO:0032635	interleukin-6 production	IMP	J:117165
Biological Process	GO:0048289	isotype switching to IgE isotypes	IMP	J:117165
Biological Process	GO:0046651	lymphocyte proliferation	IMP	J:117165
Biological Process	GO:0046651	lymphocyte proliferation	IMP	J:117165
Biological Process	GO:0046651	lymphocyte proliferation	IMP	J:112602
Biological Process	GO:0046651	lymphocyte proliferation	IMP	J:112602
Biological Process	GO:0002262	myeloid cell homeostasis	IMP	J:53219
Biological Process	GO:0046642	negative regulation of alpha-beta T cell proliferation	IMP	J:115967
Biological Process	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation	IDA	J:117627
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0002677	negative regulation of chronic inflammatory response	IDA	J:116306
Biological Process	GO:0002677	negative regulation of chronic inflammatory response	IMP	J:117165
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	ISO	J:164563
Biological Process	GO:0001818	negative regulation of cytokine production	ISO	J:164563
Biological Process	GO:0050687	negative regulation of defense response to virus	ISO	J:155856
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:89682
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:97353
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:210175
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:210175
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:210175
Biological Process	GO:0031064	negative regulation of histone deacetylation	ISO	J:164563
Biological Process	GO:0050777	negative regulation of immune response	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:102496
Biological Process	GO:0032693	negative regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032693	negative regulation of interleukin-10 production	IMP	J:117165
Biological Process	GO:0032700	negative regulation of interleukin-17 production	IMP	J:136164
Biological Process	GO:0032700	negative regulation of interleukin-17 production	ISO	J:164563
Biological Process	GO:0032703	negative regulation of interleukin-2 production	IMP	J:136164
Biological Process	GO:0032703	negative regulation of interleukin-2 production	IDA	J:121433
Biological Process	GO:0032703	negative regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:0032703	negative regulation of interleukin-2 production	IDA	J:116306
Biological Process	GO:0032703	negative regulation of interleukin-2 production	IDA	J:117627
Biological Process	GO:0032713	negative regulation of interleukin-4 production	ISO	J:164563
Biological Process	GO:0032713	negative regulation of interleukin-4 production	IMP	J:117165
Biological Process	GO:0032713	negative regulation of interleukin-4 production	IDA	J:116306
Biological Process	GO:0032714	negative regulation of interleukin-5 production	IMP	J:117165
Biological Process	GO:0032714	negative regulation of interleukin-5 production	IDA	J:116306
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:117165
Biological Process	GO:0048294	negative regulation of isotype switching to IgE isotypes	IMP	J:117165
Biological Process	GO:0050672	negative regulation of lymphocyte proliferation	IMP	J:117165
Biological Process	GO:0050672	negative regulation of lymphocyte proliferation	IMP	J:112602
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0002725	negative regulation of T cell cytokine production	ISO	J:164563
Biological Process	GO:0042130	negative regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0042130	negative regulation of T cell proliferation	IDA	J:116306
Biological Process	GO:0042130	negative regulation of T cell proliferation	IMP	J:102496
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:116306
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:117627
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:116829
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:117627
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:116829
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:116306
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:117627
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:117627
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:116829
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:117165
Biological Process	GO:0032689	negative regulation of type II interferon production	IDA	J:121433
Biological Process	GO:0032689	negative regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0032689	negative regulation of type II interferon production	IMP	J:136164
Biological Process	GO:0032689	negative regulation of type II interferon production	IDA	J:117627
Biological Process	GO:0032689	negative regulation of type II interferon production	IMP	J:117165
Biological Process	GO:0032689	negative regulation of type II interferon production	IDA	J:117627
Biological Process	GO:0032689	negative regulation of type II interferon production	IDA	J:116306
Biological Process	GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation	IDA	J:117627
Biological Process	GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	TAS	J:136164
Biological Process	GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP	J:118845
Biological Process	GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP	J:82560
Biological Process	GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP	J:117165
Biological Process	GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP	J:137389
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:121433
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:117627
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:117627
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:117627
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:165738
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:210175
Biological Process	GO:0035066	positive regulation of histone acetylation	ISO	J:164563
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus	IMP	J:116829
Biological Process	GO:0032753	positive regulation of interleukin-4 production	IMP	J:165629
Biological Process	GO:0002851	positive regulation of peripheral T cell tolerance induction	IMP	J:112554
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	ISO	J:164563
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	IDA	J:117627
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	IDA	J:116306
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	IDA	J:82045
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	IDA	J:89682
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	IMP	J:97029
Biological Process	GO:0002669	positive regulation of T cell anergy	IMP	J:115967
Biological Process	GO:0002666	positive regulation of T cell tolerance induction	IMP	J:115967
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:117627
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:115967
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:115967
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:117627
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:115967
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:115967
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:115967
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:117627
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:115967
Biological Process	GO:0032914	positive regulation of transforming growth factor beta1 production	IDA	J:117627
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0002637	regulation of immunoglobulin production	IMP	J:117165
Biological Process	GO:0048302	regulation of isotype switching to IgG isotypes	IMP	J:117165
Biological Process	GO:0002667	regulation of T cell anergy	IMP	J:121433
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IGI	J:143168
Biological Process	GO:0045066	regulatory T cell differentiation	ISO	J:164563
Biological Process	GO:0045066	regulatory T cell differentiation	IDA	J:117627
Biological Process	GO:0045066	regulatory T cell differentiation	IDA	J:116306
Biological Process	GO:0042110	T cell activation	ISO	J:164563
Biological Process	GO:0042110	T cell activation	IMP	J:53219
Biological Process	GO:0002870	T cell anergy	IMP	J:115967
Biological Process	GO:0002456	T cell mediated immunity	IMP	J:72828
Biological Process	GO:0042098	T cell proliferation	IDA	J:116306
Biological Process	GO:0042098	T cell proliferation	IMP	J:102496
Biological Process	GO:0050852	T cell receptor signaling pathway	IMP	J:67000
Biological Process	GO:0050852	T cell receptor signaling pathway	IMP	J:53219
Biological Process	GO:0002517	T cell tolerance induction	IMP	J:115967
Biological Process	GO:0002507	tolerance induction	IDA	J:98002
Biological Process	GO:0002513	tolerance induction to self antigen	IMP	J:97029
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:115967
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:117627
Biological Process	GO:0032905	transforming growth factor beta1 production	IDA	J:117627
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:117165
Biological Process	GO:0032609	type II interferon production	IDA	J:116306
Biological Process	GO:0032609	type II interferon production	IDA	J:117627
Biological Process	GO:0032609	type II interferon production	IDA	J:117627
Biological Process	GO:0032609	type II interferon production	IMP	J:117165