GO Annotations Graph

• Symbol: Lgr4
• Name: leucine-rich repeat-containing G protein-coupled receptor 4
• ID: MGI:1891468

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008201	heparin binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:198905
Molecular Function	GO:0016500	protein-hormone receptor activity	IEA	J:72247
Molecular Function	GO:0048495	Roundabout binding	IBA	J:265628
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IDA	J:198905
Molecular Function	GO:0004888	transmembrane signaling receptor activity	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:198905
Biological Process	GO:0007411	axon guidance	IBA	J:265628
Biological Process	GO:0030282	bone mineralization	IMP	J:152843
Biological Process	GO:0046849	bone remodeling	IMP	J:152843
Biological Process	GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development	IMP	J:172277
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0072202	cell differentiation involved in metanephros development	IMP	J:172277
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:216037
Biological Process	GO:0007623	circadian rhythm	IEP	J:216037
Biological Process	GO:0048565	digestive tract development	IMP	J:212415
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:105945
Biological Process	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis	IGI	J:212415
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0001942	hair follicle development	IMP	J:212415
Biological Process	GO:0001942	hair follicle development	IGI	J:212415
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0036335	intestinal stem cell homeostasis	IMP	J:212415
Biological Process	GO:0030539	male genitalia development	IMP	J:105945
Biological Process	GO:0072224	metanephric glomerulus development	IMP	J:172277
Biological Process	GO:0072282	metanephric nephron tubule morphogenesis	IMP	J:172277
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0050919	negative chemotaxis	IBA	J:265628
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:208298
Biological Process	GO:0001818	negative regulation of cytokine production	IMP	J:198965
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:172277
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	IMP	J:198965
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:152843
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IMP	J:172277
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IDA	J:198905
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IMP	J:197850
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IMP	J:174842
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:172277
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0007283	spermatogenesis	IMP	J:197850
Biological Process	GO:0035239	tube morphogenesis	IMP	J:105945
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000