GO Annotations Graph

• Symbol: Jph2
• Name: junctophilin 2
• ID: MGI:1891496

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001046	core promoter sequence-specific DNA binding	IDA	J:283181
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:283181
Molecular Function	GO:0070300	phosphatidic acid binding	ISO	J:164563
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	ISO	J:164563
Molecular Function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0032266	phosphatidylinositol-3-phosphate binding	ISO	J:164563
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	ISO	J:164563
Molecular Function	GO:0010314	phosphatidylinositol-5-phosphate binding	ISO	J:164563
Molecular Function	GO:0001786	phosphatidylserine binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:219187
Molecular Function	GO:0005515	protein binding	IPI	J:93830
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IBA	J:265628
Cellular Component	GO:0030314	junctional membrane complex	IMP	J:63879
Cellular Component	GO:0030314	junctional membrane complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	IDA	J:93830
Cellular Component	GO:0005634	nucleus	IDA	J:283181
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0016529	sarcoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:63879
Cellular Component	GO:0016529	sarcoplasmic reticulum	TAS	J:78141
Cellular Component	GO:0030018	Z disc	IDA	J:63879
Biological Process	GO:0055074	calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:283181
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:283181
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	IMP	J:63879
Biological Process	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	ISO	J:164563
Biological Process	GO:0055024	regulation of cardiac muscle tissue development	IMP	J:63879