GO Annotations Graph

• Symbol: Ncstn
• Name: nicastrin
• ID: MGI:1891700

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	IGI	J:111897
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	IGI	J:111897
Molecular Function	GO:0051117	ATPase binding	ISO	J:164563
Molecular Function	GO:0004175	endopeptidase activity	IMP	J:125592
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:150744
Molecular Function	GO:0070851	growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:206895
Molecular Function	GO:0005515	protein binding	IPI	J:200386
Molecular Function	GO:0005515	protein binding	IPI	J:177751
Molecular Function	GO:0005515	protein binding	IPI	J:93093
Molecular Function	GO:0005515	protein binding	IPI	J:177000
Molecular Function	GO:0005515	protein binding	IPI	J:177751
Molecular Function	GO:0005515	protein binding	IPI	J:93093
Molecular Function	GO:0005515	protein binding	IPI	J:93093
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005769	early endosome	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:169417
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:83641
Cellular Component	GO:0070765	gamma-secretase complex	ISO	J:164563
Cellular Component	GO:0070765	gamma-secretase complex	IDA	J:108398
Cellular Component	GO:0070765	gamma-secretase complex	IDA	J:164909
Cellular Component	GO:0070765	gamma-secretase complex	IDA	J:111897
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:83641
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:155856
Cellular Component	GO:0005764	lysosome	IDA	J:229208
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:76858
Cellular Component	GO:0016020	membrane	IDA	J:95769
Cellular Component	GO:0016020	membrane	IDA	J:100835
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-209285
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-2534209
Cellular Component	GO:0005886	plasma membrane	IDA	J:169417
Cellular Component	GO:0005886	plasma membrane	IDA	J:131375
Cellular Component	GO:0005886	plasma membrane	IDA	J:83641
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IDA	J:177000
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0097060	synaptic membrane	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	IDA	J:221387
Biological Process	GO:0030534	adult behavior	IMP	J:234705
Biological Process	GO:0042983	amyloid precursor protein biosynthetic process	IMP	J:131375
Biological Process	GO:0042987	amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:0042982	amyloid precursor protein metabolic process	ISO	J:164563
Biological Process	GO:0042982	amyloid precursor protein metabolic process	IMP	J:177000
Biological Process	GO:0034205	amyloid-beta formation	ISO	J:164563
Biological Process	GO:0034205	amyloid-beta formation	IGI	J:111897
Biological Process	GO:0034205	amyloid-beta formation	IGI	J:111897
Biological Process	GO:0050435	amyloid-beta metabolic process	IMP	J:125592
Biological Process	GO:0071277	cellular response to calcium ion	IMP	J:211635
Biological Process	GO:0022010	central nervous system myelination	IMP	J:234705
Biological Process	GO:0007212	dopamine receptor signaling pathway	IMP	J:234705
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:125592
Biological Process	GO:0050673	epithelial cell proliferation	IGI	J:125592
Biological Process	GO:0007215	glutamate receptor signaling pathway	IMP	J:211635
Biological Process	GO:0007611	learning or memory	IMP	J:149506
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0031293	membrane protein intracellular domain proteolysis	ISO	J:164563
Biological Process	GO:0002262	myeloid cell homeostasis	IMP	J:125592
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:149506
Biological Process	GO:0007220	Notch receptor processing	NAS	J:54336
Biological Process	GO:0007220	Notch receptor processing	ISO	J:164563
Biological Process	GO:0007220	Notch receptor processing	IBA	J:265628
Biological Process	GO:0007219	Notch signaling pathway	IEA	J:60000
Biological Process	GO:0042986	positive regulation of amyloid precursor protein biosynthetic process	IMP	J:210209
Biological Process	GO:0043085	positive regulation of catalytic activity	ISO	J:164563
Biological Process	GO:0010950	positive regulation of endopeptidase activity	ISO	J:164563
Biological Process	GO:0016485	protein processing	ISO	J:164563
Biological Process	GO:0016485	protein processing	IBA	J:265628
Biological Process	GO:1900271	regulation of long-term synaptic potentiation	IMP	J:211635
Biological Process	GO:1990926	short-term synaptic potentiation	IMP	J:211635
Biological Process	GO:0042098	T cell proliferation	IMP	J:125592