GO Annotations Graph

• Symbol: Rbx1
• Name: ring-box 1
• ID: MGI:1891829

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0097602	cullin family protein binding	IBA	J:265628
Molecular Function	GO:0097602	cullin family protein binding	ISO	J:73065
Molecular Function	GO:0008190	eukaryotic initiation factor 4E binding	TAS	J:113807
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0061663	NEDD8 ligase activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:195093
Molecular Function	GO:0005515	protein binding	IPI	J:90054
Molecular Function	GO:0005515	protein binding	IPI	J:149890
Molecular Function	GO:0005515	protein binding	IPI	J:90054
Molecular Function	GO:0005515	protein binding	IPI	J:111403
Molecular Function	GO:0005515	protein binding	IPI	J:94679
Molecular Function	GO:0005515	protein binding	IPI	J:111403
Molecular Function	GO:0005515	protein binding	IPI	J:149890
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:73065
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	TAS	J:113804
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Molecular Function	GO:0034450	ubiquitin-ubiquitin ligase activity	ISO	J:73065
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005680	anaphase-promoting complex	TAS	J:113804
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	EXP	J:320034
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0031466	Cul5-RING ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0031467	Cul7-RING ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0031461	cullin-RING ubiquitin ligase complex	IBA	J:265628
Cellular Component	GO:0031461	cullin-RING ubiquitin ligase complex	ISO	J:73065
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:163142
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008677
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008715
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008717
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	NAS	J:320034
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	IDA	J:163142
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	ISS	J:64811
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	IPI	J:111403
Cellular Component	GO:0000151	ubiquitin ligase complex	TAS	J:113804
Cellular Component	GO:0030891	VCB complex	ISO	J:155856
Biological Process	GO:0034644	cellular response to UV	EXP	J:320034
Biological Process	GO:0034644	cellular response to UV	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	EXP	J:320034
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0032480	negative regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:1902499	positive regulation of protein autoubiquitination	ISO	J:164563
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0030163	protein catabolic process	IMP	J:94679
Biological Process	GO:0070936	protein K48-linked ubiquitination	ISO	J:164563
Biological Process	GO:0070936	protein K48-linked ubiquitination	IDA	J:259707
Biological Process	GO:0006513	protein monoubiquitination	ISO	J:164563
Biological Process	GO:0006513	protein monoubiquitination	IGI	J:172833
Biological Process	GO:0045116	protein neddylation	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	IDA	J:163142
Biological Process	GO:0016567	protein ubiquitination	IBA	J:265628
Biological Process	GO:0016567	protein ubiquitination	ISS	J:64811
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA	J:163142
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	TAS	J:113804
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IBA	J:265628